| pubmed-article:1716182 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1716182 | lifeskim:mentions | umls-concept:C0115305 | lld:lifeskim |
| pubmed-article:1716182 | lifeskim:mentions | umls-concept:C0125090 | lld:lifeskim |
| pubmed-article:1716182 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:1716182 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:1716182 | lifeskim:mentions | umls-concept:C0007004 | lld:lifeskim |
| pubmed-article:1716182 | lifeskim:mentions | umls-concept:C0134835 | lld:lifeskim |
| pubmed-article:1716182 | lifeskim:mentions | umls-concept:C0282651 | lld:lifeskim |
| pubmed-article:1716182 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:1716182 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1716182 | pubmed:dateCreated | 1991-10-11 | lld:pubmed |
| pubmed-article:1716182 | pubmed:abstractText | LECAM-1 (leukocyte-endothelial cell adhesion molecule 1), the lymphocyte lectin ("selectin") homing receptor for peripheral lymph nodes (PLNs), participates in the earliest interactions of polymorphonuclear neutrophilic leukocytes (PMNs) with inflamed venules. Here, we present evidence that LECAM-1 mediates this function through a novel mechanism--presentation of oligosaccharide ligands to the inducible vascular selectins endothelial-leukocyte adhesion molecule (ELAM-1) and granule membrane protein 140 (GMP-140). PMN, but not lymphocyte, LECAM-1 is modified with the vascular selectin ligand sialyl Lewis x (sLex) and specifically binds ELAM-1-transfected cells. Although only a small fraction of total cell surface sLex, LECAM-1-associated sLex appears to play a prominent role in PMN interactions with cell-associated ELAM-1 and GMP-140, as anti-LECAM-1 monoclonal antibodies or selective removal of cell surface LECAM-1 inhibits PMN binding to vascular selectin transfectants by up to 70%. The enhanced function of LECAM-1-associated sLex may reflect the striking concentration, shown here, of LECAM-1 on PMN surface microvilli, the site of initial cellular contact. | lld:pubmed |
| pubmed-article:1716182 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1716182 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1716182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716182 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1716182 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1716182 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:1716182 | pubmed:author | pubmed-author:ButcherE CEC | lld:pubmed |
| pubmed-article:1716182 | pubmed:author | pubmed-author:BurnsA RAR | lld:pubmed |
| pubmed-article:1716182 | pubmed:author | pubmed-author:DoerschukC... | lld:pubmed |
| pubmed-article:1716182 | pubmed:author | pubmed-author:PickerL JLJ | lld:pubmed |
| pubmed-article:1716182 | pubmed:author | pubmed-author:BergE LEL | lld:pubmed |
| pubmed-article:1716182 | pubmed:author | pubmed-author:WarnockR ARA | lld:pubmed |
| pubmed-article:1716182 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1716182 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:1716182 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:1716182 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1716182 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1716182 | pubmed:pagination | 921-33 | lld:pubmed |
| pubmed-article:1716182 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:meshHeading | pubmed-meshheading:1716182-... | lld:pubmed |
| pubmed-article:1716182 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1716182 | pubmed:articleTitle | The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. | lld:pubmed |
| pubmed-article:1716182 | pubmed:affiliation | Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072. | lld:pubmed |
| pubmed-article:1716182 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1716182 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1716182 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1716182 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716182 | lld:pubmed |
