| pubmed-article:17161604 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17161604 | lifeskim:mentions | umls-concept:C0679215 | lld:lifeskim |
| pubmed-article:17161604 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:17161604 | lifeskim:mentions | umls-concept:C0027270 | lld:lifeskim |
| pubmed-article:17161604 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17161604 | pubmed:dateCreated | 2007-1-9 | lld:pubmed |
| pubmed-article:17161604 | pubmed:abstractText | Nicotinamide adenine dinucleotide (NAD(+)) is both a coenzyme for hydride-transfer enzymes and a substrate for NAD(+)-consuming enzymes, which include ADP-ribose transferases, poly(ADP-ribose) polymerases, cADP-ribose synthases and sirtuins. Recent results establish protective roles for NAD(+) that might be applicable therapeutically to prevent neurodegenerative conditions and to fight Candida glabrata infection. In addition, the contribution that NAD(+) metabolism makes to lifespan extension in model systems indicates that therapies to boost NAD(+) might promote some of the beneficial effects of calorie restriction. Nicotinamide riboside, the recently discovered nucleoside precursor of NAD(+) in eukaryotic systems, might have advantages as a therapy to elevate NAD(+) without inhibiting sirtuins, which is associated with high-dose nicotinamide, or incurring the unpleasant side-effects of high-dose nicotinic acid. | lld:pubmed |
| pubmed-article:17161604 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17161604 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17161604 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17161604 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17161604 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17161604 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17161604 | pubmed:issn | 0968-0004 | lld:pubmed |
| pubmed-article:17161604 | pubmed:author | pubmed-author:BrennerCharle... | lld:pubmed |
| pubmed-article:17161604 | pubmed:author | pubmed-author:BelenkyPeterP | lld:pubmed |
| pubmed-article:17161604 | pubmed:author | pubmed-author:BoganKatrina... | lld:pubmed |
| pubmed-article:17161604 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17161604 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:17161604 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17161604 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17161604 | pubmed:pagination | 12-9 | lld:pubmed |
| pubmed-article:17161604 | pubmed:dateRevised | 2008-3-6 | lld:pubmed |
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| pubmed-article:17161604 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17161604 | pubmed:articleTitle | NAD+ metabolism in health and disease. | lld:pubmed |
| pubmed-article:17161604 | pubmed:affiliation | Departments of Genetics and of Biochemistry and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA. | lld:pubmed |
| pubmed-article:17161604 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17161604 | pubmed:publicationType | Review | lld:pubmed |
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