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pubmed-article:17161064pubmed:abstractTextReduction of drug-induced adverse events may be achievable through a better understanding of the underlying causes of such events. Identifying phenotypes and genotypes that allow event prediction would provide greater safety margins for new therapeutics. Torsades de pointes (TdP) is one such life-threatening adverse event and can arise from excessive lengthening of the QT interval. This study was designed to better understand the role of genetics in the development of TdP and to determine whether genotypes can be used to predict susceptibility and thus reduce adverse events.lld:pubmed
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pubmed-article:17161064pubmed:articleTitleAssociation of torsades de pointes with novel and known single nucleotide polymorphisms in long QT syndrome genes.lld:pubmed
pubmed-article:17161064pubmed:affiliationPharmacogenomics, Molecular Profiling, Groton, CT, USA.lld:pubmed
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