| pubmed-article:17159907 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17159907 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:17159907 | lifeskim:mentions | umls-concept:C0245662 | lld:lifeskim |
| pubmed-article:17159907 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:17159907 | lifeskim:mentions | umls-concept:C0332621 | lld:lifeskim |
| pubmed-article:17159907 | lifeskim:mentions | umls-concept:C1622858 | lld:lifeskim |
| pubmed-article:17159907 | lifeskim:mentions | umls-concept:C0598435 | lld:lifeskim |
| pubmed-article:17159907 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:17159907 | lifeskim:mentions | umls-concept:C1548602 | lld:lifeskim |
| pubmed-article:17159907 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17159907 | pubmed:dateCreated | 2007-1-10 | lld:pubmed |
| pubmed-article:17159907 | pubmed:abstractText | Apoptosis signaling through CD95 (Fas/APO-1) involves aggregation and clustering of the receptor followed by its actin-dependent internalization. Internalization is required for efficient formation of the death-inducing signaling complex (DISC) with maximal recruitment of FADD, caspase-8/10 and c-FLIP occurring when the receptor has reached an endosomal compartment. The first detectable event during CD95 signaling is the formation of SDS-stable aggregates likely reflecting intense oligomerization of the receptor. We now demonstrate that these SDS-stable forms of CD95 correspond to very high molecular weight DISC complexes (hiDISC) and are the sites of caspase-8 activation. hiDISCs are found both inside and outside of detergent-resistant membranes. The formation of SDS-stable CD95 aggregates involves palmitoylation of the membrane proximal cysteine 199 in CD95. Cysteine 199 mutants no longer form SDS-stable aggregates, and inhibition of palmitoylation reduces internalization of CD95 and activation of caspase-8. Our data demonstrate that SDS-stable forms of CD95 are the sites of apoptosis initiation and represent an important early step in apoptosis signaling through CD95 before activation of caspases. | lld:pubmed |
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| pubmed-article:17159907 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17159907 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17159907 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17159907 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17159907 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:17159907 | pubmed:author | pubmed-author:PeterMarcus... | lld:pubmed |
| pubmed-article:17159907 | pubmed:author | pubmed-author:SchützeStefan... | lld:pubmed |
| pubmed-article:17159907 | pubmed:author | pubmed-author:FeigChristine... | lld:pubmed |
| pubmed-article:17159907 | pubmed:author | pubmed-author:TchikovVladim... | lld:pubmed |
| pubmed-article:17159907 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17159907 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:17159907 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17159907 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17159907 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17159907 | pubmed:pagination | 221-31 | lld:pubmed |
| pubmed-article:17159907 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17159907 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17159907 | pubmed:articleTitle | Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling. | lld:pubmed |
| pubmed-article:17159907 | pubmed:affiliation | The Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637, USA. | lld:pubmed |
| pubmed-article:17159907 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17159907 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17159907 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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