| pubmed-article:17151130 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C0037224 | lld:lifeskim |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C1517745 | lld:lifeskim |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C0024398 | lld:lifeskim |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:17151130 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17151130 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17151130 | pubmed:dateCreated | 2007-1-29 | lld:pubmed |
| pubmed-article:17151130 | pubmed:abstractText | Although combination therapy allows the suppression of human immunodeficiency virus type 1 (HIV-1) viremia to undetectable levels, eradication has not been achieved because the virus persists in cellular reservoirs, particularly the latent reservoir in resting CD4(+) T lymphocytes. We previously established a simian immunodeficiency virus (SIV)/macaque model to study latency. We describe here a novel mechanism for the induction of SIV from latently infected resting CD4(+) T cells. Several human cell lines including CEMx174 and Epstein-Barr virus-transformed human B-lymphoblastoid cell lines mediated contact-dependent activation of resting macaque T cells and induction of latent SIV. Antibody-blocking assays showed that interactions between the costimulatory molecule CD2 and its ligand CD58 were involved, whereas soluble factors and interactions between T-cell receptors and major histocompatibility complex class II were not. Combinations of specific antibodies to CD2 also induced T-cell activation and virus induction in human resting CD4(+) T cells carrying latent HIV-1. This is the first demonstration that costimulatory signals can induce latent virus without the coengagement of the T-cell receptor, and this study might provide insights into potential pathways to target latent HIV-1. | lld:pubmed |
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| pubmed-article:17151130 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17151130 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17151130 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17151130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17151130 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17151130 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17151130 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17151130 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:17151130 | pubmed:author | pubmed-author:ZhangHaoH | lld:pubmed |
| pubmed-article:17151130 | pubmed:author | pubmed-author:MargolickJose... | lld:pubmed |
| pubmed-article:17151130 | pubmed:author | pubmed-author:ZinkM... | lld:pubmed |
| pubmed-article:17151130 | pubmed:author | pubmed-author:ClementsJanic... | lld:pubmed |
| pubmed-article:17151130 | pubmed:author | pubmed-author:ZhouYanY | lld:pubmed |
| pubmed-article:17151130 | pubmed:author | pubmed-author:SilicianoRobe... | lld:pubmed |
| pubmed-article:17151130 | pubmed:author | pubmed-author:BoyerJean DJD | lld:pubmed |
| pubmed-article:17151130 | pubmed:author | pubmed-author:ShenAndingA | lld:pubmed |
| pubmed-article:17151130 | pubmed:author | pubmed-author:YangHung-Chih... | lld:pubmed |
| pubmed-article:17151130 | pubmed:author | pubmed-author:ChaseAmanda... | lld:pubmed |
| pubmed-article:17151130 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17151130 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:17151130 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17151130 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17151130 | pubmed:pagination | 1660-70 | lld:pubmed |
| pubmed-article:17151130 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
