Linked Life Data

17145892

Source:http://linkedlifedata.com/resource/pubmed/id/17145892

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17145892rdf:typepubmed:Citationlld:pubmed
pubmed-article:17145892lifeskim:mentionsumls-concept:C0030705lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C0037047lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C1332717lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C1706438lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C0039194lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C1282910lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C0085358lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C1704632lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C0871261lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C1413244lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C2698600lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C2911692lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C1706817lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C0439859lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C1707455lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C1533691lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C1515895lld:lifeskim
pubmed-article:17145892lifeskim:mentionsumls-concept:C1708943lld:lifeskim
pubmed-article:17145892pubmed:issue23lld:pubmed
pubmed-article:17145892pubmed:dateCreated2006-12-5lld:pubmed
pubmed-article:17145892pubmed:abstractTextAllogeneic cell therapy as a means to break immunotolerance to solid tumors is increasingly used for cancer treatment. To investigate cellular alloimmune responses in a human tumor model, primary cultures were established from renal cell carcinoma (RCC) tissues of 56 patients. In three patients with stable RCC line and human leukocyte antigen (HLA)-identical sibling donor available, allogeneic and autologous RCC reactivities were compared using mixed lymphocyte/tumor cell cultures (MLTC). Responding lymphocytes were exclusively CD8(+) T cells, whereas CD4(+) T cells or natural killer cells were never observed. Sibling MLTC populations showed higher proliferative and cytolytic antitumor responses compared with their autologous counterparts. The allo-MLTC responders originated from the CD8(+) CD62L(high)(+) peripheral blood subpopulation containing naive precursor and central memory T cells. Limiting dilution cloning failed to establish CTL clones from autologous MLTCs or tumor-infiltrating lymphocytes. In contrast, a broad panel of RCC-reactive CTL clones was expanded from each allogeneic MLTC. These sibling CTL clones either recognized exclusively the original RCC tumor line or cross-reacted with nonmalignant kidney cells of patient origin. A minority of CTL clones also recognized patient-derived hematopoietic cells or other allogeneic tumor targets. The MHC-restricting alleles for RCC-reactive sibling CTL clones included HLA-A2, HLA-A3, HLA-A11, HLA-A24, and HLA-B7. In one sibling donor-RCC pair, strongly proliferative CD3(+)CD16(+)CD57(+) CTL clones with non-HLA-restricted antitumor reactivity were established. Our results show superior tumor-reactive CD8 responses of matched allogeneic compared with autologous T cells. These data encourage the generation of antitumor T-cell products from HLA-identical siblings and their potential use in adoptive immunotherapy of metastatic RCC patients.lld:pubmed
pubmed-article:17145892pubmed:languageenglld:pubmed
pubmed-article:17145892pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17145892pubmed:citationSubsetIMlld:pubmed
pubmed-article:17145892pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17145892pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17145892pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17145892pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17145892pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17145892pubmed:statusMEDLINElld:pubmed
pubmed-article:17145892pubmed:monthDeclld:pubmed
pubmed-article:17145892pubmed:issn0008-5472lld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:HerrWolfgangWlld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:HuberChristop...lld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:FalkChristine...lld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:BrennerWalbur...lld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:RanieriElenaElld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:MelchiorSebas...lld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:StrandSusanne...lld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:NonnMarionMlld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:MeyerRalfRlld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:SchnürerElkeElld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:LennerzVolker...lld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:WehlerThomasTlld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:GröneMarkMlld:pubmed
pubmed-article:17145892pubmed:authorpubmed-author:KauscheSandra...lld:pubmed
pubmed-article:17145892pubmed:issnTypePrintlld:pubmed
pubmed-article:17145892pubmed:day1lld:pubmed
pubmed-article:17145892pubmed:volume66lld:pubmed
pubmed-article:17145892pubmed:ownerNLMlld:pubmed
pubmed-article:17145892pubmed:authorsCompleteYlld:pubmed
pubmed-article:17145892pubmed:pagination11447-54lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:meshHeadingpubmed-meshheading:17145892...lld:pubmed
pubmed-article:17145892pubmed:year2006lld:pubmed
pubmed-article:17145892pubmed:articleTitleSuperior antitumor in vitro responses of allogeneic matched sibling compared with autologous patient CD8+ T cells.lld:pubmed
pubmed-article:17145892pubmed:affiliationDepartment of Medicine III, Hematology and Oncology, University of Mainz, Mainz, Germany.lld:pubmed
pubmed-article:17145892pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17145892pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:17145892pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17145892lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17145892lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17145892lld:pubmed