| pubmed-article:17145774 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17145774 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:17145774 | lifeskim:mentions | umls-concept:C0215343 | lld:lifeskim |
| pubmed-article:17145774 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:17145774 | lifeskim:mentions | umls-concept:C2244392 | lld:lifeskim |
| pubmed-article:17145774 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:17145774 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17145774 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:17145774 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17145774 | pubmed:dateCreated | 2007-1-31 | lld:pubmed |
| pubmed-article:17145774 | pubmed:abstractText | How cells die in the absence of oxygen (anoxia) is not understood. Here we report that cells deficient in Bax and Bak or caspase-9 do not undergo anoxia-induced cell death. However, the caspase-9 null cells do not survive reoxygenation due to the generation of mitochondrial reactive oxygen species. The individual loss of Bim, Bid, Puma, Noxa, Bad, caspase-2, or hypoxia-inducible factor 1beta, which are potential upstream regulators of Bax or Bak, did not prevent anoxia-induced cell death. Anoxia triggered the loss of the Mcl-1 protein upstream of Bax/Bak activation. Cells containing a mitochondrial DNA cytochrome b 4-base-pair deletion ([rho(-)] cells) and cells depleted of their entire mitochondrial DNA ([rho(0)] cells) are oxidative phosphorylation incompetent and displayed loss of the Mcl-1 protein under anoxia. [rho(0)] cells, in contrast to [rho(-)] cells, did not die under anoxia. However, [rho(0)] cells did undergo cell death in the presence of the Bad BH3 peptide, an inhibitor of Bcl-X(L)/Bcl-2 proteins. These results indicate that [rho(0)] cells survive under anoxia despite the loss of Mcl-1 protein due to residual prosurvival activity of the Bcl-X(L)/Bcl-2 proteins. Collectively, these results demonstrate that anoxia-induced cell death requires the loss of Mcl-1 protein and inhibition of the electron transport chain to negate Bcl-X(L)/Bcl-2 proteins. | lld:pubmed |
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| pubmed-article:17145774 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17145774 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17145774 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17145774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17145774 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17145774 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17145774 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:17145774 | pubmed:author | pubmed-author:ThompsonCraig... | lld:pubmed |
| pubmed-article:17145774 | pubmed:author | pubmed-author:ChandelNavdee... | lld:pubmed |
| pubmed-article:17145774 | pubmed:author | pubmed-author:FlavellRichar... | lld:pubmed |
| pubmed-article:17145774 | pubmed:author | pubmed-author:StrasserAndre... | lld:pubmed |
| pubmed-article:17145774 | pubmed:author | pubmed-author:MoraesCarlos... | lld:pubmed |
| pubmed-article:17145774 | pubmed:author | pubmed-author:DanialNika... | lld:pubmed |
| pubmed-article:17145774 | pubmed:author | pubmed-author:PerlmanHarris... | lld:pubmed |
| pubmed-article:17145774 | pubmed:author | pubmed-author:KeithBrianB | lld:pubmed |
| pubmed-article:17145774 | pubmed:author | pubmed-author:BrunelleJosly... | lld:pubmed |
| pubmed-article:17145774 | pubmed:author | pubmed-author:ShroffEmelyn... | lld:pubmed |
