| pubmed-article:17145771 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17145771 | lifeskim:mentions | umls-concept:C1704689 | lld:lifeskim |
| pubmed-article:17145771 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:17145771 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:17145771 | lifeskim:mentions | umls-concept:C0020852 | lld:lifeskim |
| pubmed-article:17145771 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:17145771 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:17145771 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:17145771 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:17145771 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:17145771 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:17145771 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17145771 | pubmed:dateCreated | 2007-1-31 | lld:pubmed |
| pubmed-article:17145771 | pubmed:abstractText | Activation of extracellular signal-regulated protein kinase (ERK) has been implicated in proliferation as well as differentiation in a wide variety of cell types. Using B-cell-specific gene-targeted mice, we report here that in T-cell-dependent immune responses, ERK2 is required to generate efficient immunoglobulin G (IgG) production. In its absence, the proportion of antigen-specific surface IgG1-bearing cells and the subsequent number of IgG1 antibody-secreting cells were decreased, despite apparently unimpaired class switch recombination. Notably, this defect was countered by overexpression of the antiapoptotic factor Bcl-2. Together, our results suggest that ERK2 plays a key role in efficient generation of antigen-specific IgG-bearing B cells by promoting their survival. | lld:pubmed |
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| pubmed-article:17145771 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17145771 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17145771 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17145771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17145771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17145771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17145771 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17145771 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17145771 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:17145771 | pubmed:author | pubmed-author:AibaYuichiY | lld:pubmed |
| pubmed-article:17145771 | pubmed:author | pubmed-author:KurosakiTomoh... | lld:pubmed |
| pubmed-article:17145771 | pubmed:author | pubmed-author:SanjoHidekiH | lld:pubmed |
| pubmed-article:17145771 | pubmed:author | pubmed-author:OgataMasatoM | lld:pubmed |
| pubmed-article:17145771 | pubmed:author | pubmed-author:MoriYoshikoY | lld:pubmed |
| pubmed-article:17145771 | pubmed:author | pubmed-author:HatanoNaoyaN | lld:pubmed |
| pubmed-article:17145771 | pubmed:author | pubmed-author:HikidaMasakiM | lld:pubmed |
| pubmed-article:17145771 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17145771 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:17145771 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17145771 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17145771 | pubmed:pagination | 1236-46 | lld:pubmed |
| pubmed-article:17145771 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17145771 | pubmed:year | 2007 | lld:pubmed |
