Linked Life Data

17143267

Source:http://linkedlifedata.com/resource/pubmed/id/17143267

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17143267rdf:typepubmed:Citationlld:pubmed
pubmed-article:17143267lifeskim:mentionsumls-concept:C0995242lld:lifeskim
pubmed-article:17143267lifeskim:mentionsumls-concept:C0013936lld:lifeskim
pubmed-article:17143267lifeskim:mentionsumls-concept:C2755352lld:lifeskim
pubmed-article:17143267pubmed:issue1lld:pubmed
pubmed-article:17143267pubmed:dateCreated2007-1-2lld:pubmed
pubmed-article:17143267pubmed:abstractTextDNA methylation is an important means of epigenetic gene regulation and must be carefully controlled as a prerequisite for normal early embryogenesis. Although global demethylation occurs soon after fertilization, it is not evenly distributed throughout the genome. Genomic imprinting and epigenetic asymmetry between parental genomes, that is, delayed demethylation of the maternal genome after fertilization, are clear examples of the functional importance of DNA methylation. Here, we show that PGC7/Stella, a maternal factor essential for early development, protects the DNA methylation state of several imprinted loci and epigenetic asymmetry. After determining that PGC7/Stella binds to Ran binding protein 5 (RanBP5; a nuclear transport shuttle protein), mutant versions of the two proteins were used to examine exactly when and where PGC7/Stella functions within the cell. It is likely that PGC7/Stella protects the maternal genome from demethylation only after localizing to the nucleus, where it maintains the methylation of several imprinted genes. These results demonstrate that PGC7/Stella is indispensable for the maintenance of methylation involved in epigenetic reprogramming after fertilization.lld:pubmed
pubmed-article:17143267pubmed:languageenglld:pubmed
pubmed-article:17143267pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17143267pubmed:citationSubsetIMlld:pubmed
pubmed-article:17143267pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17143267pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17143267pubmed:statusMEDLINElld:pubmed
pubmed-article:17143267pubmed:monthJanlld:pubmed
pubmed-article:17143267pubmed:issn1465-7392lld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:YonedaYoshihi...lld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:OkabeMasaruMlld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:TanakaSatoshi...lld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:ShiotaKunioKlld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:NakamuraToshi...lld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:IkawaMasahito...lld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:KimuraTohruTlld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:MasuharaMasaa...lld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:NakanoToruTlld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:TaniguchiHisa...lld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:AraiYoshikazu...lld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:SekimotoToshi...lld:pubmed
pubmed-article:17143267pubmed:authorpubmed-author:UmeharaHiroki...lld:pubmed
pubmed-article:17143267pubmed:issnTypePrintlld:pubmed
pubmed-article:17143267pubmed:volume9lld:pubmed
pubmed-article:17143267pubmed:ownerNLMlld:pubmed
pubmed-article:17143267pubmed:authorsCompleteYlld:pubmed
pubmed-article:17143267pubmed:pagination64-71lld:pubmed
pubmed-article:17143267pubmed:dateRevised2008-5-13lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:meshHeadingpubmed-meshheading:17143267...lld:pubmed
pubmed-article:17143267pubmed:year2007lld:pubmed
pubmed-article:17143267pubmed:articleTitlePGC7/Stella protects against DNA demethylation in early embryogenesis.lld:pubmed
pubmed-article:17143267pubmed:affiliationDepartment of Pathology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka 565-0871, Japan. tnakano@patho.med.osaka-u.ac.jplld:pubmed
pubmed-article:17143267pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17143267pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:3843entrezgene:pubmedpubmed-article:17143267lld:entrezgene
entrez-gene:359787entrezgene:pubmedpubmed-article:17143267lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:17143267lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:17143267lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17143267lld:pubmed