| pubmed-article:17141508 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17141508 | lifeskim:mentions | umls-concept:C0220806 | lld:lifeskim |
| pubmed-article:17141508 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:17141508 | lifeskim:mentions | umls-concept:C0085151 | lld:lifeskim |
| pubmed-article:17141508 | lifeskim:mentions | umls-concept:C0243041 | lld:lifeskim |
| pubmed-article:17141508 | lifeskim:mentions | umls-concept:C1708096 | lld:lifeskim |
| pubmed-article:17141508 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17141508 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17141508 | lifeskim:mentions | umls-concept:C1705920 | lld:lifeskim |
| pubmed-article:17141508 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:17141508 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:17141508 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17141508 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17141508 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17141508 | pubmed:dateCreated | 2007-1-26 | lld:pubmed |
| pubmed-article:17141508 | pubmed:abstractText | Oxidative stress, protein misfolding, protein complex formation, and detergent insolubility are biochemical features of Alzheimer's disease (AD). We tested the cause-and-effect relationships among these using MC65 human neuroblastoma cells that exhibit toxicity upon conditional expression of carboxy-terminal fragments (CTFs) of the human amyloid precursor protein (APP). Treatments with three different antioxidants (alpha-tocopherol, N-acetyl cysteine, and alpha-lipoic acid) or three different compounds (glycerol, trimethylamine-N-oxide, and 4-phenylbutyric acid) that have been described to have a "chemical chaperone" function in promoting protein folding all had a protective effect on MC65 cells and decreased markers of oxidative damage and accumulation of high molecular weight amyloid (A) beta-immunoreactive (IR) species. However, chaperones partially reduced detergent insolubility of the remaining Abeta-IR species, while antioxidants did not. These results suggest that protein misfolding associated with overexpression of APP CTFs promotes oxidative stress and cytotoxicity and contributes to formation of detergent-insoluble species that appear unrelated to cytotoxicity. | lld:pubmed |
| pubmed-article:17141508 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17141508 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141508 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17141508 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141508 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17141508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17141508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17141508 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17141508 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17141508 | pubmed:issn | 0969-9961 | lld:pubmed |
| pubmed-article:17141508 | pubmed:author | pubmed-author:MontineThomas... | lld:pubmed |
| pubmed-article:17141508 | pubmed:author | pubmed-author:MontineKathle... | lld:pubmed |
| pubmed-article:17141508 | pubmed:author | pubmed-author:MilatovicDeja... | lld:pubmed |
| pubmed-article:17141508 | pubmed:author | pubmed-author:ShieFeng-Shiu... | lld:pubmed |
| pubmed-article:17141508 | pubmed:author | pubmed-author:WoltjerRandal... | lld:pubmed |
| pubmed-article:17141508 | pubmed:author | pubmed-author:McMahanWendyW | lld:pubmed |
| pubmed-article:17141508 | pubmed:author | pubmed-author:KjerulfJohn... | lld:pubmed |
| pubmed-article:17141508 | pubmed:author | pubmed-author:RungLisa GLG | lld:pubmed |
| pubmed-article:17141508 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17141508 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:17141508 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17141508 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17141508 | pubmed:pagination | 427-37 | lld:pubmed |
| pubmed-article:17141508 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:17141508 | pubmed:meshHeading | pubmed-meshheading:17141508... | lld:pubmed |
| pubmed-article:17141508 | pubmed:meshHeading | pubmed-meshheading:17141508... | lld:pubmed |
| pubmed-article:17141508 | pubmed:meshHeading | pubmed-meshheading:17141508... | lld:pubmed |
| pubmed-article:17141508 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17141508 | pubmed:articleTitle | Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment. | lld:pubmed |
| pubmed-article:17141508 | pubmed:affiliation | Department of Pathology, University of Washington, Box 359645, Harborview Medical Center, 300 Ninth Avenue, Seattle, WA 98104, USA. rwoltjer@u.washington.edu | lld:pubmed |
| pubmed-article:17141508 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17141508 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17141508 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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