| pubmed-article:17137798 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17137798 | lifeskim:mentions | umls-concept:C0033774 | lld:lifeskim |
| pubmed-article:17137798 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:17137798 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:17137798 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:17137798 | lifeskim:mentions | umls-concept:C0023689 | lld:lifeskim |
| pubmed-article:17137798 | lifeskim:mentions | umls-concept:C0041538 | lld:lifeskim |
| pubmed-article:17137798 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:17137798 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:17137798 | lifeskim:mentions | umls-concept:C1425008 | lld:lifeskim |
| pubmed-article:17137798 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17137798 | pubmed:dateCreated | 2006-12-18 | lld:pubmed |
| pubmed-article:17137798 | pubmed:abstractText | Nedd4 family interacting protein-1 (Ndfip1) is a protein whose only known function is that it binds Nedd4, a HECT-type E3 ubiquitin ligase. Here we show that mice lacking Ndfip1 developed severe inflammation of the skin and lung and died prematurely. This condition was due to a defect in Ndfip1(-/-) T cells. Ndfip1(-/-) T cells were activated, and they proliferated and adopted a T helper 2 (Th2) phenotype more readily than did their Ndfip1(+/+) counterparts. This phenotype resembled that of Itchy mutant mice, suggesting that Ndfip1 might affect the function of Itch, an E3 ubiquitin ligase. We show that T cell activation promoted both Ndfip1 expression and its association with Itch. In the absence of Ndfip1, JunB half-life was prolonged after T cell activation. Thus, in the absence of Ndfip1, Itch is inactive and JunB accumulates. As a result, T cells produce Th2 cytokines and promote Th2-mediated inflammatory disease. | lld:pubmed |
| pubmed-article:17137798 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17137798 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17137798 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17137798 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17137798 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17137798 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17137798 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17137798 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17137798 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17137798 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17137798 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17137798 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17137798 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17137798 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17137798 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17137798 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17137798 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:17137798 | pubmed:author | pubmed-author:MarrackPhilip... | lld:pubmed |
| pubmed-article:17137798 | pubmed:author | pubmed-author:KapplerJohnJ | lld:pubmed |
| pubmed-article:17137798 | pubmed:author | pubmed-author:OliverPaula... | lld:pubmed |
| pubmed-article:17137798 | pubmed:author | pubmed-author:KirbyPatricia... | lld:pubmed |
| pubmed-article:17137798 | pubmed:author | pubmed-author:YangBaoliB | lld:pubmed |
| pubmed-article:17137798 | pubmed:author | pubmed-author:WhiteJaniceJ | lld:pubmed |
| pubmed-article:17137798 | pubmed:author | pubmed-author:CaoXiaoX | lld:pubmed |
| pubmed-article:17137798 | pubmed:author | pubmed-author:MacLeodMeganM | lld:pubmed |
| pubmed-article:17137798 | pubmed:author | pubmed-author:WorthenGeorge... | lld:pubmed |
| pubmed-article:17137798 | pubmed:author | pubmed-author:ShiPeijunP | lld:pubmed |
| pubmed-article:17137798 | pubmed:author | pubmed-author:BrionesNatali... | lld:pubmed |
| pubmed-article:17137798 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17137798 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:17137798 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17137798 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17137798 | pubmed:pagination | 929-40 | lld:pubmed |
| pubmed-article:17137798 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:meshHeading | pubmed-meshheading:17137798... | lld:pubmed |
| pubmed-article:17137798 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17137798 | pubmed:articleTitle | Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. | lld:pubmed |
| pubmed-article:17137798 | pubmed:affiliation | Howard Hughes Medical Institute, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA. | lld:pubmed |
| pubmed-article:17137798 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17137798 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17137798 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:16396 | entrezgene:pubmed | pubmed-article:17137798 | lld:entrezgene |
| entrez-gene:65113 | entrezgene:pubmed | pubmed-article:17137798 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17137798 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17137798 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17137798 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17137798 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17137798 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17137798 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17137798 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17137798 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17137798 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17137798 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17137798 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17137798 | lld:pubmed |
