pubmed-article:17131118 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17131118 | lifeskim:mentions | umls-concept:C1261468 | lld:lifeskim |
pubmed-article:17131118 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
pubmed-article:17131118 | lifeskim:mentions | umls-concept:C0597032 | lld:lifeskim |
pubmed-article:17131118 | lifeskim:mentions | umls-concept:C0338106 | lld:lifeskim |
pubmed-article:17131118 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
pubmed-article:17131118 | lifeskim:mentions | umls-concept:C1282910 | lld:lifeskim |
pubmed-article:17131118 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
pubmed-article:17131118 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
pubmed-article:17131118 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
pubmed-article:17131118 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
pubmed-article:17131118 | lifeskim:mentions | umls-concept:C2348767 | lld:lifeskim |
pubmed-article:17131118 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
pubmed-article:17131118 | pubmed:issue | 7 | lld:pubmed |
pubmed-article:17131118 | pubmed:dateCreated | 2007-4-26 | lld:pubmed |
pubmed-article:17131118 | pubmed:abstractText | Cancer immunotherapy by dendritic cell (DC)/tumor cell fusion hybrids (DC/TC hybrids) has been shown to elicit potent anti-tumor effects via the induction of immune responses against multiple tumor-associated antigens. In the present study, we compared the anti-tumor effects of vaccinating Balb/c mice (H-2(d)) with CT26CL25 colon carcinoma cells that had been fused with either syngeneic DCs from Balb/c mice, allogeneic DCs from C57BL/6 mice (H-2(b)) or semiallogeneic DCs from B6D2F1 mice (H-2(b/d)). Preimmunization with either semiallogeneic or allogeneic DC/TC hybrids induced complete protection from tumor challenge, whereas mice preimmunized with syngeneic DC/TC hybrids were only partially protected (75% tumor rejection). The average number of pulmonary metastases after intravenous tumor injection decreased significantly following immunization with semiallogeneic or allogeneic DC/TC hybrids (8.3 +/- 7.9 or 16.3 +/- 3.5, mean +/- SD) relative to syngeneic DC/TC hybrids (67.8 +/- 6.3). These data demonstrate that vaccination with semiallogeneic DC/TC hybrids resulted in the greatest anti-tumor efficacy. Anti-tumor effects showed by in vivo studies were virtually accomplished by the frequency of induced CTLs specific to both gp70 and beta-galactosidase assessed by using pentameric assay. Among the fusion vaccines tested, semiallogeneic DC/TC hybrids induced the highest ratio of Th1 cytokine IFN-gamma to Th2 cytokine IL-10. In addition, allogeneic or semiallogeneic DC/TC hybrids elicited a significantly stronger NK activity than syngeneic DC/TC hybrids. These findings suggest that in clinical settings, DCs derived from a healthy donor (which are generally characterized as more semiallogeneic than allogeneic) may be more capable than autologous DCs of inducing promising anti-tumor effects in vaccinations with DC/TC hybrids. | lld:pubmed |
pubmed-article:17131118 | pubmed:language | eng | lld:pubmed |
pubmed-article:17131118 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17131118 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:17131118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17131118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17131118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17131118 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17131118 | pubmed:month | Jul | lld:pubmed |
pubmed-article:17131118 | pubmed:issn | 0340-7004 | lld:pubmed |
pubmed-article:17131118 | pubmed:author | pubmed-author:KamigakiTakas... | lld:pubmed |
pubmed-article:17131118 | pubmed:author | pubmed-author:KurodaYoshika... | lld:pubmed |
pubmed-article:17131118 | pubmed:author | pubmed-author:AjikiTetsuoT | lld:pubmed |
pubmed-article:17131118 | pubmed:author | pubmed-author:NakamuraTetsu... | lld:pubmed |
pubmed-article:17131118 | pubmed:author | pubmed-author:YamamotoMasas... | lld:pubmed |
pubmed-article:17131118 | pubmed:author | pubmed-author:KimYongsikY | lld:pubmed |
pubmed-article:17131118 | pubmed:author | pubmed-author:KurodaDaisuke... | lld:pubmed |
pubmed-article:17131118 | pubmed:author | pubmed-author:YasudaTakashi... | lld:pubmed |
pubmed-article:17131118 | pubmed:author | pubmed-author:KawasakiKenta... | lld:pubmed |
pubmed-article:17131118 | pubmed:author | pubmed-author:TakaseShiroS | lld:pubmed |
pubmed-article:17131118 | pubmed:author | pubmed-author:KanemitsuKiyo... | lld:pubmed |
pubmed-article:17131118 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17131118 | pubmed:volume | 56 | lld:pubmed |
pubmed-article:17131118 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17131118 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17131118 | pubmed:pagination | 1025-36 | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:meshHeading | pubmed-meshheading:17131118... | lld:pubmed |
pubmed-article:17131118 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17131118 | pubmed:articleTitle | Superior anti-tumor protection and therapeutic efficacy of vaccination with allogeneic and semiallogeneic dendritic cell/tumor cell fusion hybrids for murine colon adenocarcinoma. | lld:pubmed |
pubmed-article:17131118 | pubmed:affiliation | Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kobe University, Kusunoki-cho 7-5-1, Chuo-ku, Kobe 650-0017, Japan. yasudatyamane@yahoo.co.jp | lld:pubmed |
pubmed-article:17131118 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17131118 | pubmed:publicationType | Comparative Study | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17131118 | lld:pubmed |