Linked Life Data

17126992

Source:http://linkedlifedata.com/resource/pubmed/id/17126992

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pubmed-article:17126992pubmed:abstractTextWidespread DNA copy number alterations are well recognized in hepatocellular carcinoma (HCC), although the affected genes expression remained largely undefined. In this study, we performed genome-wide analysis on HCC to examine the relationship between gene copy number and corresponding transcriptional changes. To ensure analysis on a homogenous population of tumor cells, integrative analysis of array-based CGH and expression profilings was performed on 20 HCC cell lines using a 19,200-element cDNA microarray platform. Further validation studies were carried out on a large series of primary HCC tumors and paired adjacent non-malignant liver to ascertain finding. Correlative analyses highlighted 31 candidate genes that manifested both copy gains and gene up-regulations (R2>0.5; p<0.05). Of interest was over-expressed paternally expressed 10 (PEG10) resided within the chromosome region 7q21 that has been implicated in the progression of HCC. Quantitative PCR and qRT-PCR studies verified concurrent genomic gains and over-expression of PEG10 in HCC cell lines and primary tumors (34/40 cases; 85%). In addition, qRT-PCR demonstrated a significant progressive trend of increasing PEG10 expressions from the putative pre-malignant adjacent livers to early resectable HCC tumors, and to late inoperable HCCs (p=0.007). In summary, the present study demonstrated the usefulness of integrated genomic and expression profilings in identifying candidate genes within regions of genomic alteration. Our results also suggested that PEG10 may be a potential biomarker in the progressive development of HCC, and that genomic gain represents one of the major mechanisms in the induction of PEG10 over-expressions.lld:pubmed
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pubmed-article:17126992pubmed:year2007lld:pubmed
pubmed-article:17126992pubmed:articleTitleIdentification of PEG10 as a progression related biomarker for hepatocellular carcinoma.lld:pubmed
pubmed-article:17126992pubmed:affiliationDepartment of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.lld:pubmed
pubmed-article:17126992pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17126992pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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