Linked Life Data

1712502

Source:http://linkedlifedata.com/resource/pubmed/id/1712502

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SubjectPredicateObjectContext
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pubmed-article:1712502pubmed:issue9lld:pubmed
pubmed-article:1712502pubmed:dateCreated1991-8-9lld:pubmed
pubmed-article:1712502pubmed:abstractTextWe have recently shown that priming mice with allogeneic strain A spleen cells before immunization with (A x B)F1 spleen cells strongly suppresses the cytotoxic T-lymphocyte (CTL) response directed against linked strain B alloantigens. This specific decrease in the CTL responses against the second immunizing alloantigen is associated with a high CTL response against the first priming alloantigen. The suppression of CTL responses against the strain B alloantigens is, however, not due to killing of F1 spleen cells by anti-A CTL, since it was observed after immunization of primed mice with a mixture of (A x B)F1 and B cells. In the present study, attempts were made to determine the relative contribution of H-2 and minor histocompatibility background antigens towards induction of suppression. Our results demonstrate that priming and immunizing spleen cells have only to share H-2 antigens in order to induce a downregulation of CTL responses directed against the linked alloantigens. This indicates that immunity against H-2 antigens is sufficient to induce suppression. However, priming against minor histocompatibility antigens also induces suppression, but only if spleen cells used for priming and immunization share H-2 antigens with the recipient strain. Therefore, the suppression can be induced by priming with non-H-2 antigens but is H-2-restricted. This study has also demonstrated that suppression can be induced by intraperitoneal or subcutaneous administration of allogeneic cells.lld:pubmed
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pubmed-article:1712502pubmed:authorpubmed-author:LeclercCClld:pubmed
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pubmed-article:1712502pubmed:volume141lld:pubmed
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pubmed-article:1712502pubmed:authorsCompleteYlld:pubmed
pubmed-article:1712502pubmed:pagination839-53lld:pubmed
pubmed-article:1712502pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:1712502pubmed:articleTitleRole of major and minor histocompatibility antigens in the suppression of alloreactive cytotoxic responses induced by alloantigen pretreatment.lld:pubmed
pubmed-article:1712502pubmed:affiliationLaboratoire de Biologie des Régulations Immunitaires, Institut Pasteur, Paris.lld:pubmed
pubmed-article:1712502pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1712502pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed