| pubmed-article:17110450 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17110450 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:17110450 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:17110450 | lifeskim:mentions | umls-concept:C0242303 | lld:lifeskim |
| pubmed-article:17110450 | lifeskim:mentions | umls-concept:C1819433 | lld:lifeskim |
| pubmed-article:17110450 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17110450 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17110450 | pubmed:dateCreated | 2007-3-7 | lld:pubmed |
| pubmed-article:17110450 | pubmed:abstractText | Natural killer (NK) cells contribute to host immunity, including tumor surveillance, through the production of interferon gamma (IFN-gamma). Although there is some knowledge about molecular mechanisms that induce IFN-gamma in NK cells, considerably less is known about the mechanisms that reduce its expression. Here, we investigate the role of the Hlx transcription factor in IFN-gamma production by NK cells. Hlx expression is induced in monokine-activated NK cells, but with delayed kinetics compared to IFN-gamma. Ectopic Hlx expression decreases IFN-gamma synthesis in primary human NK cells and IFN-gamma promoter activity in an NK-like cell line. Hlx protein levels inversely correlate with those of STAT4, a requisite factor for optimal IFN-gamma transcription. Mechanistically, we provide evidence indicating that Hlx overexpression accelerates dephosphorylation and proteasome-dependent degradation of the active Y693-phosphorylated form of STAT4. Thus, Hlx expression in activated NK cells temporally controls and limits the monokine-induced production of IFN-gamma, in part through the targeted depletion of STAT4. | lld:pubmed |
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| pubmed-article:17110450 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17110450 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17110450 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17110450 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17110450 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17110450 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17110450 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:PerrottiDanil... | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:TrottaRossana... | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:CaligiuriMich... | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:BatesMichael... | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:BecknellBrian... | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:BlaserBradley... | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:JarjouraDavid... | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:FreudAharon... | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:YuJianhuaJ | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:LehmanAmyA | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:MaoHsiaoyin... | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:HughesTiffany... | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:BensonDon... | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:Caligiuri... | lld:pubmed |
| pubmed-article:17110450 | pubmed:author | pubmed-author:AlghothaniMoh... | lld:pubmed |
| pubmed-article:17110450 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17110450 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17110450 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:17110450 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17110450 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17110450 | pubmed:pagination | 2481-7 | lld:pubmed |
| pubmed-article:17110450 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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