| pubmed-article:17108143 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17108143 | lifeskim:mentions | umls-concept:C0085828 | lld:lifeskim |
| pubmed-article:17108143 | lifeskim:mentions | umls-concept:C0037657 | lld:lifeskim |
| pubmed-article:17108143 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:17108143 | lifeskim:mentions | umls-concept:C0034840 | lld:lifeskim |
| pubmed-article:17108143 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:17108143 | lifeskim:mentions | umls-concept:C1515844 | lld:lifeskim |
| pubmed-article:17108143 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17108143 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:17108143 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:17108143 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:17108143 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:17108143 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:17108143 | pubmed:dateCreated | 2006-11-19 | lld:pubmed |
| pubmed-article:17108143 | pubmed:abstractText | Steroid receptor coactivator (SRC)-3, also called amplified in breast cancer 1, is a member of the p160 nuclear receptor coactivator family involved in transcriptional regulation of target genes. SRC-3 is frequently amplified and/or overexpressed in hormone-sensitive and hormone-insensitive tumors. We reported previously that SRC-3 stimulated prostate cell growth in a hormone-independent manner through activation of AKT signaling pathway. However, the underlying mechanism remains undefined. Here, we exploited the mifepristone-induced SRC-3 LNCaP prostate cancer cell line generated in our laboratory to identify SRC-3-regulated genes by oligonucleotide microarray analysis. We found that SRC-3 up-regulates the expression of multiple genes in the insulin-like growth factor (IGF)/AKT signaling pathway that are involved in cell proliferation and survival. In contrast, knockdown of SRC-3 in PC3 (androgen receptor negative) prostate cancer cells and MCF-7 breast cancer cells reduces their expression. Similarly, in prostate glands of SRC-3 null mice, expressions of these components in the IGF/AKT signal pathway are also reduced. Chromatin immunoprecipitation assay revealed that SRC-3 was directly recruited to the promoters of these genes, indicating that they are direct targets of SRC-3. Interestingly, we showed that recruitment of SRC-3 to two target promoters, IRS-2 and IGF-I, requires transcription factor activator protein-1 (AP-1). Taken together, our results clearly show that SRC-3 and AP-1 can coordinately regulate the transcription of multiple components in the IGF/AKT pathway to ensure ligand-independent cell proliferation and survival of cancer cells. | lld:pubmed |
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| pubmed-article:17108143 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17108143 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17108143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17108143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17108143 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17108143 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17108143 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:17108143 | pubmed:author | pubmed-author:KuoZ FZF | lld:pubmed |
| pubmed-article:17108143 | pubmed:author | pubmed-author:TsaiMing-JerM... | lld:pubmed |
| pubmed-article:17108143 | pubmed:author | pubmed-author:TsaiSophia... | lld:pubmed |
| pubmed-article:17108143 | pubmed:author | pubmed-author:YuCheng-TaiCT | lld:pubmed |
| pubmed-article:17108143 | pubmed:author | pubmed-author:IttmannMichae... | lld:pubmed |
| pubmed-article:17108143 | pubmed:author | pubmed-author:OzenMustafaM | lld:pubmed |
| pubmed-article:17108143 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17108143 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17108143 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:17108143 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17108143 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17108143 | pubmed:pagination | 11039-46 | lld:pubmed |
| pubmed-article:17108143 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17108143 | pubmed:meshHeading | pubmed-meshheading:17108143... | lld:pubmed |
| pubmed-article:17108143 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17108143 | pubmed:articleTitle | Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway. | lld:pubmed |
| pubmed-article:17108143 | pubmed:affiliation | Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA. | lld:pubmed |
| pubmed-article:17108143 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17108143 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:17979 | entrezgene:pubmed | pubmed-article:17108143 | lld:entrezgene |
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