| pubmed-article:17107404 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17107404 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:17107404 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:17107404 | lifeskim:mentions | umls-concept:C1881155 | lld:lifeskim |
| pubmed-article:17107404 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17107404 | pubmed:dateCreated | 2006-11-19 | lld:pubmed |
| pubmed-article:17107404 | pubmed:abstractText | We report a new immunological treatment for advanced cutaneous melanoma which combines laser stimulation with topical application of a toll-like receptor agonist. This treatment, in situ photoimmunotherapy (ISPI), provides an alternative to traditional therapies for melanoma patients with cutaneous metastases. A 6-week cycle of ISPI is carried out on cutaneous metastases located in a designated 20 x 20 cm treatment area: 2 weeks of pretreatment with twice-daily topical applications of imiquimod (5% cream under plastic occlusion), with a laser treatment session at week 2 and again at week 4. Topical imiquimod is continued for the entire 6-week cycle. Two patients with late-stage melanoma were treated with ISPI. Patient 1 had the primary tumour and local metastases on the left arm, as well as metastatic tumours in the lungs [American Joint Committee on Cancer (AJCC) stage IV]. Patient 2 had a head and neck melanoma with multiple local metastases (AJCC stage IIIC), which had failed repeated attempts at surgical resection and high-dose radiation therapy. Patient 1 is now free of all clinically detectable tumours (including the lung metastases) >20 months after the first treatment cycle. Patient 2 has been free of any clinical evidence of the tumour for over 6 months. These two cases demonstrate that ISPI can clear local tumour and trigger beneficial systemic responses, with a side-effect profile that compares favourably with other treatments for advanced melanoma. | lld:pubmed |
| pubmed-article:17107404 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17107404 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17107404 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17107404 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17107404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17107404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17107404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17107404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17107404 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17107404 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17107404 | pubmed:issn | 0007-0963 | lld:pubmed |
| pubmed-article:17107404 | pubmed:author | pubmed-author:NordquistR... | lld:pubmed |
| pubmed-article:17107404 | pubmed:author | pubmed-author:PerryL ALA | lld:pubmed |
| pubmed-article:17107404 | pubmed:author | pubmed-author:ChenW RWR | lld:pubmed |
| pubmed-article:17107404 | pubmed:author | pubmed-author:TeagueT KTK | lld:pubmed |
| pubmed-article:17107404 | pubmed:author | pubmed-author:NaylorM FMF | lld:pubmed |
| pubmed-article:17107404 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17107404 | pubmed:volume | 155 | lld:pubmed |
| pubmed-article:17107404 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17107404 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17107404 | pubmed:pagination | 1287-92 | lld:pubmed |
| pubmed-article:17107404 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:17107404 | pubmed:meshHeading | pubmed-meshheading:17107404... | lld:pubmed |
| pubmed-article:17107404 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17107404 | pubmed:articleTitle | In situ photoimmunotherapy: a tumour-directed treatment for melanoma. | lld:pubmed |
| pubmed-article:17107404 | pubmed:affiliation | Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA. marknaylor@earthlink.net | lld:pubmed |
| pubmed-article:17107404 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17107404 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:17107404 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17107404 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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