| pubmed-article:17106262 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17106262 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:17106262 | lifeskim:mentions | umls-concept:C1336767 | lld:lifeskim |
| pubmed-article:17106262 | lifeskim:mentions | umls-concept:C0679199 | lld:lifeskim |
| pubmed-article:17106262 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17106262 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:17106262 | pubmed:dateCreated | 2006-12-25 | lld:pubmed |
| pubmed-article:17106262 | pubmed:abstractText | While diverse enzymatic activities are required for transcriptional initiation, a central question remains whether additional enzymatic activities involved in other cellular processes may also be critical for regulated gene activation. Recently, we reported that signal-dependent activation of gene transcription requires topoisomerase IIbeta (Topo IIbeta)-dependent, nucleosome-specific, transient double-stranded DNA break formation with subsequent activation of poly(ADP-ribose) polymerase-1 (PARP-1) enzymatic function, which causes local changes of chromatin architecture (Ju et al., Science 2006; 312:1798-802). Here, we discussed that possible molecular mechanism underling Topo IIbeta/PARP-1/DNA-PK network in transcriptional initiation and many intriguing issues remain to be solved in the future. | lld:pubmed |
| pubmed-article:17106262 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17106262 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17106262 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17106262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17106262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17106262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17106262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17106262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17106262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17106262 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17106262 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17106262 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17106262 | pubmed:issn | 1551-4005 | lld:pubmed |
| pubmed-article:17106262 | pubmed:author | pubmed-author:RosenfeldMich... | lld:pubmed |
| pubmed-article:17106262 | pubmed:author | pubmed-author:JuBong-GunBG | lld:pubmed |
| pubmed-article:17106262 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17106262 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:17106262 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17106262 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17106262 | pubmed:pagination | 2557-60 | lld:pubmed |
| pubmed-article:17106262 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:meshHeading | pubmed-meshheading:17106262... | lld:pubmed |
| pubmed-article:17106262 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17106262 | pubmed:articleTitle | A breaking strategy for topoisomerase IIbeta/PARP-1-dependent regulated transcription. | lld:pubmed |
| pubmed-article:17106262 | pubmed:affiliation | Howard Hughes Medical Institute, Department of Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093-0648, USA. | lld:pubmed |
| pubmed-article:17106262 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17106262 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17106262 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17106262 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17106262 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17106262 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17106262 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17106262 | lld:pubmed |
