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pubmed-article:17094465pubmed:abstractText4-1BB (CD137) is a member of the tumor necrosis factor receptor superfamily. It interacts with 4-1BB ligand (4-1BBL) and delivers a costimulatory signal for T cell activation. The immune response induced by 4-1BB monoclonal antibodies (mAbs) has been shown to have a marked augmentation of tumor-selective cytolytic T cell activity.lld:pubmed
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pubmed-article:17094465pubmed:articleTitleAugmented antitumor effects of radiation therapy by 4-1BB antibody (BMS-469492) treatment.lld:pubmed
pubmed-article:17094465pubmed:affiliationDepartment of Radiation Oncology, Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA.lld:pubmed
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