| pubmed-article:1709244 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1709244 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:1709244 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:1709244 | lifeskim:mentions | umls-concept:C1335808 | lld:lifeskim |
| pubmed-article:1709244 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1709244 | lifeskim:mentions | umls-concept:C1154393 | lld:lifeskim |
| pubmed-article:1709244 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1709244 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1709244 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1709244 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1709244 | pubmed:dateCreated | 1991-6-10 | lld:pubmed |
| pubmed-article:1709244 | pubmed:abstractText | The human leukocyte adhesion molecule-1 (LAM-1, TQ1, Leu-8) is involved in the binding of human leukocytes to high endothelial venules (HEV) of peripheral lymph nodes (LN). The regulation of LAM-1 expression is unique in that leukocyte stimulation induces a rapid down-modulation of LAM-1 from the cell surface. In this study, the regulation and function of LAM-1 was studied in detail in normal lymphocytes and compared with the LAM-1 of malignant leukocytes. Modulation of LAM-1 from the cell surface occurred concomitantly with the appearance of LAM-1 in the culture medium indicating that LAM-1 is cleaved from the cell surface. Shedding of LAM-1 was decreased in the presence of protein kinase C (PKC) inhibitors. As with normal lymphocytes, cells transfected with the LAM-1 cDNA and chronic lymphocytic leukemia (CLL) cells also shed LAM-1 following phorbol myristate acetate (PMA) exposure. CLL cells expressed the same Mr LAM-1 protein as normal lymphocytes and LAM-1+ CLL cells were able to specifically bind to HEV. In addition, normal lymphocytes and LAM-1+ CLL cells were capable of binding polyphosphomonester core polysaccharide (PPME) derived from yeast cell wall, a carbohydrate which mimics an essential component of the natural ligand for LAM-1, and PPME and HEV binding was specifically blocked by a new monoclonal antibody (mAb) reactive with LAM-1. The expression of LAM-1 and other adhesion molecules was examined on cells of 118 hematopoietic malignancies. LAM-1 was most frequently expressed on CLL and follicular or diffuse small cleaved cell lymphomas, whereas most other malignancies were LAM-1-. Thus, most CLL cells and some non-Hodgkin's lymphoma cells express a functionally active LAM-1 molecule which may correlate with their capacity to migrate through the circulation and disseminate into peripheral LN. | lld:pubmed |
| pubmed-article:1709244 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709244 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709244 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709244 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1709244 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709244 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1709244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709244 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1709244 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1709244 | pubmed:issn | 0887-6924 | lld:pubmed |
| pubmed-article:1709244 | pubmed:author | pubmed-author:PentaA CAC | lld:pubmed |
| pubmed-article:1709244 | pubmed:author | pubmed-author:GriffinJ DJD | lld:pubmed |
| pubmed-article:1709244 | pubmed:author | pubmed-author:FreedmanA SAS | lld:pubmed |
| pubmed-article:1709244 | pubmed:author | pubmed-author:TedderT FTF | lld:pubmed |
| pubmed-article:1709244 | pubmed:author | pubmed-author:SpertiniOO | lld:pubmed |
| pubmed-article:1709244 | pubmed:author | pubmed-author:BelvinM PMP | lld:pubmed |
| pubmed-article:1709244 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1709244 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:1709244 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1709244 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1709244 | pubmed:pagination | 300-8 | lld:pubmed |
| pubmed-article:1709244 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:1709244 | pubmed:meshHeading | pubmed-meshheading:1709244-... | lld:pubmed |
| pubmed-article:1709244 | pubmed:meshHeading | pubmed-meshheading:1709244-... | lld:pubmed |
| pubmed-article:1709244 | pubmed:meshHeading | pubmed-meshheading:1709244-... | lld:pubmed |
| pubmed-article:1709244 | pubmed:meshHeading | pubmed-meshheading:1709244-... | lld:pubmed |
| pubmed-article:1709244 | pubmed:meshHeading | pubmed-meshheading:1709244-... | lld:pubmed |
| pubmed-article:1709244 | pubmed:meshHeading | pubmed-meshheading:1709244-... | lld:pubmed |
| pubmed-article:1709244 | pubmed:meshHeading | pubmed-meshheading:1709244-... | lld:pubmed |
| pubmed-article:1709244 | pubmed:meshHeading | pubmed-meshheading:1709244-... | lld:pubmed |
| pubmed-article:1709244 | pubmed:meshHeading | pubmed-meshheading:1709244-... | lld:pubmed |
| pubmed-article:1709244 | pubmed:meshHeading | pubmed-meshheading:1709244-... | lld:pubmed |
| pubmed-article:1709244 | pubmed:meshHeading | pubmed-meshheading:1709244-... | lld:pubmed |
| pubmed-article:1709244 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1709244 | pubmed:articleTitle | Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells. | lld:pubmed |
| pubmed-article:1709244 | pubmed:affiliation | Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115. | lld:pubmed |
| pubmed-article:1709244 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1709244 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1709244 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1709244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1709244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1709244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1709244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1709244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1709244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1709244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1709244 | lld:pubmed |
