| pubmed-article:1709018 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1709018 | lifeskim:mentions | umls-concept:C0034439 | lld:lifeskim |
| pubmed-article:1709018 | lifeskim:mentions | umls-concept:C0038585 | lld:lifeskim |
| pubmed-article:1709018 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:1709018 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:1709018 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1709018 | pubmed:dateCreated | 1991-6-6 | lld:pubmed |
| pubmed-article:1709018 | pubmed:abstractText | Two members of a new class of non-peptide antagonists of substance P, (+-)-cis-3-(2-methoxybenzylamino)-2-benzhydrylquinuclidine [(+/-)-CP-96,345; I] and (+-)-cis-3-(2-chlorobenzylamino)-2-benzhydrylquinuclidine [II], were tested for their ability to antagonize neurokinin-induced contractions of the rabbit cava and jugular veins (NK-1), the rabbit pulmonary artery (NK-2) and the rat portal vein (NK-3 system). Compound 1 is the most potent NK-1 receptor antagonist identified until now; its apparent affinity (pA2 = 9.52) is at least two log units higher than those of other NK-1 antagonists. Compound II is less active. Both compounds have been found to be almost inactive as NK-2 and NK-3 antagonists and should, therefore, be considered as selective for the NK-1 receptor. The new compounds have no direct myotropic effects and are specific for neurokinin (NK-1) receptors since they do not affect the myotropic effects of angiotensin, noradrenaline and bradykinin in the rabbit cava and jugular veins. | lld:pubmed |
| pubmed-article:1709018 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1709018 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709018 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1709018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1709018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1709018 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1709018 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1709018 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:1709018 | pubmed:author | pubmed-author:RegoliDD | lld:pubmed |
| pubmed-article:1709018 | pubmed:author | pubmed-author:GitterB DBD | lld:pubmed |
| pubmed-article:1709018 | pubmed:author | pubmed-author:WatersD CDC | lld:pubmed |
| pubmed-article:1709018 | pubmed:author | pubmed-author:RouissiNN | lld:pubmed |
| pubmed-article:1709018 | pubmed:author | pubmed-author:HowbertJ JJJ | lld:pubmed |
| pubmed-article:1709018 | pubmed:author | pubmed-author:NixonJ AJA | lld:pubmed |
| pubmed-article:1709018 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1709018 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:1709018 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:1709018 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1709018 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1709018 | pubmed:pagination | 894-901 | lld:pubmed |
| pubmed-article:1709018 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1709018 | pubmed:meshHeading | pubmed-meshheading:1709018-... | lld:pubmed |
| pubmed-article:1709018 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1709018 | pubmed:articleTitle | Selectivity and specificity of new, non-peptide, quinuclidine antagonists of substance P. | lld:pubmed |
| pubmed-article:1709018 | pubmed:affiliation | Department of Pharmacology, Medical School, University of Sherbrooke, Quebec, Canada. | lld:pubmed |
| pubmed-article:1709018 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1709018 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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