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pubmed-article:1708847pubmed:abstractTextThree peptide neuromodulators that are found in high concentration in the substantia nigra: dynorphin A 1-8, met5-enkephalin-arg6-gly7-leu8 and substance P, were measured by specific radioimmunoassays in nigral tissue from normals and schizophrenics postmortem. Substance P and dynorphin were unchanged between the two groups. However, the proenkephalin-derived peptide was significantly elevated in the schizophrenic group. The immunoreactivity was identified as authentic met5-enkephalin-arg6-gly7-leu8 by high pressure liquid chromatography. The data suggest that a different set of regulatory controls exists for nigral enkephalin peptides as compared to dynorphin and substance P, and that the former system may be disordered in schizophrenia.lld:pubmed
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pubmed-article:1708847pubmed:authorpubmed-author:KleinmanJ EJElld:pubmed
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pubmed-article:1708847pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:1708847pubmed:articleTitleEnkephalin, dynorphin and substance P in postmortem substantia nigra from normals and schizophrenic patients.lld:pubmed
pubmed-article:1708847pubmed:affiliationNeurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.lld:pubmed
pubmed-article:1708847pubmed:publicationTypeJournal Articlelld:pubmed
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