| pubmed-article:17077274 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17077274 | lifeskim:mentions | umls-concept:C0079941 | lld:lifeskim |
| pubmed-article:17077274 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:17077274 | lifeskim:mentions | umls-concept:C1158013 | lld:lifeskim |
| pubmed-article:17077274 | lifeskim:mentions | umls-concept:C0206243 | lld:lifeskim |
| pubmed-article:17077274 | lifeskim:mentions | umls-concept:C0449255 | lld:lifeskim |
| pubmed-article:17077274 | lifeskim:mentions | umls-concept:C1519595 | lld:lifeskim |
| pubmed-article:17077274 | lifeskim:mentions | umls-concept:C0332291 | lld:lifeskim |
| pubmed-article:17077274 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:17077274 | pubmed:dateCreated | 2006-11-30 | lld:pubmed |
| pubmed-article:17077274 | pubmed:abstractText | Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs carrying premature translation termination codons. Generally, NMD is elicited if translation terminates >50-54 nucleotides (nt) upstream of an exon-exon junction. We have previously reported that human beta-globin mRNAs carrying 5'-proximal nonsense mutations (e.g., beta15) accumulate to normal levels, suggesting an exception to the "50-54-nt boundary rule." In the present report, we demonstrate that the strength of the UPF1-dependent NMD of mutant beta-globin mRNAs is specifically determined by the proximity of the nonsense codon to the initiation AUG. This conclusion is supported by a parallel effect of the short ORF size on NMD of nonsense-containing alpha-globin mRNAs. To determine whether the short-ORF effect on NMD response is conserved in heterologous transcripts, we assessed its effects on a set of beta-globin/triosephosphate isomerase (TPI) hybrid mRNAs and on the TPI mRNA. Our data support the conclusion that nonsense mutations resulting in a short ORF are able to circumvent the full activity of the canonical UPF1-dependent NMD pathway. | lld:pubmed |
| pubmed-article:17077274 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17077274 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17077274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17077274 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17077274 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17077274 | pubmed:issn | 1355-8382 | lld:pubmed |
| pubmed-article:17077274 | pubmed:author | pubmed-author:MorgansD JDJ | lld:pubmed |
| pubmed-article:17077274 | pubmed:author | pubmed-author:LiebhaberStep... | lld:pubmed |
| pubmed-article:17077274 | pubmed:author | pubmed-author:FaustinoPaula... | lld:pubmed |
| pubmed-article:17077274 | pubmed:author | pubmed-author:RomãoLuísaL | lld:pubmed |
| pubmed-article:17077274 | pubmed:author | pubmed-author:KongJianJ | lld:pubmed |
| pubmed-article:17077274 | pubmed:author | pubmed-author:SilvaAna... | lld:pubmed |
| pubmed-article:17077274 | pubmed:author | pubmed-author:MartinsRuteR | lld:pubmed |
| pubmed-article:17077274 | pubmed:author | pubmed-author:PereiraFranci... | lld:pubmed |
| pubmed-article:17077274 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17077274 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:17077274 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17077274 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17077274 | pubmed:pagination | 2160-70 | lld:pubmed |
| pubmed-article:17077274 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:meshHeading | pubmed-meshheading:17077274... | lld:pubmed |
| pubmed-article:17077274 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17077274 | pubmed:articleTitle | The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context. | lld:pubmed |
| pubmed-article:17077274 | pubmed:affiliation | Centro de Genética Humana, Instituto Nacional de Saúde Dr. Ricardo Jorge, 1649-016 Lisboa, Portugal. | lld:pubmed |
| pubmed-article:17077274 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17077274 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17077274 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17077274 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17077274 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17077274 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17077274 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17077274 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17077274 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17077274 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17077274 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17077274 | lld:pubmed |
