| pubmed-article:1707692 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1707692 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:1707692 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1707692 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:1707692 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1707692 | lifeskim:mentions | umls-concept:C2243049 | lld:lifeskim |
| pubmed-article:1707692 | lifeskim:mentions | umls-concept:C0030899 | lld:lifeskim |
| pubmed-article:1707692 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:1707692 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:1707692 | lifeskim:mentions | umls-concept:C0699487 | lld:lifeskim |
| pubmed-article:1707692 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:1707692 | pubmed:dateCreated | 1991-5-21 | lld:pubmed |
| pubmed-article:1707692 | pubmed:abstractText | Pentoxifylline (Trental), used routinely for the treatment of intermittent claudication, has been shown previously to decrease the levels of tumor necrosis factors-alpha (TNF-alpha) RNA in cancer patients and to lead to a general improvement of well being. Increased TNF-alpha levels have been observed not only in cancer patients but also in cachectic patients with the acquired immunodeficiency syndrome (AIDS), and TNF-alpha is known to increase the expression of the human immunodeficiency virus type 1 (HIV-1) via activating its long terminal repeat (LTR). Moreover, TNF-alpha decreases the therapeutic efficacy of zidovudine (AZT). Here we show a significant decrease in HIV-1 replication by pentoxifylline in infected human peripheral blood mononuclear cells. The reduction was proportional to the downregulation of expression of a reporter gene, the bacterial gene for chloramphenicol acetyl transferase, linked to the HIV-1 LTR in human monocytoid cells. We conclude that patients with AIDS may benefit from pentoxifylline treatment because of its blockage of TNF-alpha-mediated HIV-1 upregulation, from increased efficacy of AZT, and also from improvement in TNF-alpha-induced cachexia. | lld:pubmed |
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| pubmed-article:1707692 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1707692 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1707692 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1707692 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1707692 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1707692 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:1707692 | pubmed:author | pubmed-author:PardeeA BAB | lld:pubmed |
| pubmed-article:1707692 | pubmed:author | pubmed-author:RuprechtR MRM | lld:pubmed |
| pubmed-article:1707692 | pubmed:author | pubmed-author:DezubeB JBJ | lld:pubmed |
| pubmed-article:1707692 | pubmed:author | pubmed-author:Allen-RyanJJ | lld:pubmed |
| pubmed-article:1707692 | pubmed:author | pubmed-author:FazelyFF | lld:pubmed |
| pubmed-article:1707692 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1707692 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1707692 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:1707692 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1707692 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1707692 | pubmed:pagination | 1653-6 | lld:pubmed |
| pubmed-article:1707692 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1707692 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1707692 | pubmed:articleTitle | Pentoxifylline (Trental) decreases the replication of the human immunodeficiency virus type 1 in human peripheral blood mononuclear cells and in cultured T cells. | lld:pubmed |
| pubmed-article:1707692 | pubmed:affiliation | Division of Cancer Pharmacology, Dana-Farber Cancer Institute, Beth Israel Hospital, Boston, MA 02115. | lld:pubmed |
| pubmed-article:1707692 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1707692 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1707692 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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