| pubmed-article:17065408 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17065408 | lifeskim:mentions | umls-concept:C0078058 | lld:lifeskim |
| pubmed-article:17065408 | lifeskim:mentions | umls-concept:C0032005 | lld:lifeskim |
| pubmed-article:17065408 | lifeskim:mentions | umls-concept:C0032019 | lld:lifeskim |
| pubmed-article:17065408 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:17065408 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:17065408 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:17065408 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:17065408 | lifeskim:mentions | umls-concept:C1171892 | lld:lifeskim |
| pubmed-article:17065408 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:17065408 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17065408 | pubmed:dateCreated | 2006-10-26 | lld:pubmed |
| pubmed-article:17065408 | pubmed:abstractText | As for any solid tumour, pituitary adenoma expansion is dependent on neovascularization through angiogenesis. In this process, vascular endothelial growth factor (VEGF) and its receptors VEGFR-1, VEGFR-2 and neuropilin-1 (NRP-1) may play an outstanding role. The intention of this work was to study the expression/localization and possible function of VEGF receptors in pituitary adenomas. VEGF receptor mRNA and protein expression was studied by in situ hybridization, immunohistochemistry and RT-PCR in 6 normal human pituitaries, 39 human pituitary adenomas and 4 rodent pituitary adenoma cell lines. VEGFR-1 expressing somatotroph MtT-S cells were used as a model to study the role of VEGF on cell proliferation and to elucidate the underlying mechanism of action. In normal pituitaries, VEGFR-1 was detected in endocrine cells, whereas VEGFR-2 and NRP-1 were exclusively expressed in endothelial cells. In pituitary tumours, a heterogeneous VEGFR expression pattern was observed by IHC. VEGFR-1, VEGFR-2 and NRP-1 were detected in 24, 18 and 17 adenomas respectively. In the adenomas, VEGFR-1 was expressed in epithelial tumour cells and VEGFR-2/NRP-1 in vessel endothelial cells. Functional studies in VEGFR-1-positive MtT-S cells showed that the ligands of VEGFR-1 significantly stimulated cell proliferation. This effect was mediated through the phosphatidylinositol-3-kinase-signalling pathway and involves induction of cyclin D1 and Bcl-2. Based on our results, we speculate that the ligands of VEGF receptors, such as VEGF-A and placenta growth factor, not only play a role in angiogenesis in pituitary adenomas, but also affect the growth of pituitary tumour cells through VEGFR-1. | lld:pubmed |
| pubmed-article:17065408 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17065408 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17065408 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17065408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17065408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17065408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17065408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17065408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17065408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17065408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17065408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17065408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17065408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17065408 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17065408 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17065408 | pubmed:issn | 0022-0795 | lld:pubmed |
| pubmed-article:17065408 | pubmed:author | pubmed-author:LosaMarcoM | lld:pubmed |
| pubmed-article:17065408 | pubmed:author | pubmed-author:LangeManfredM | lld:pubmed |
| pubmed-article:17065408 | pubmed:author | pubmed-author:ArztEduardoE | lld:pubmed |
| pubmed-article:17065408 | pubmed:author | pubmed-author:StallaGünter... | lld:pubmed |
| pubmed-article:17065408 | pubmed:author | pubmed-author:UhlEberhardE | lld:pubmed |
| pubmed-article:17065408 | pubmed:author | pubmed-author:OnofriChiaraC | lld:pubmed |
| pubmed-article:17065408 | pubmed:author | pubmed-author:RennerUlrichU | lld:pubmed |
| pubmed-article:17065408 | pubmed:author | pubmed-author:Theodoropoulo... | lld:pubmed |
| pubmed-article:17065408 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17065408 | pubmed:volume | 191 | lld:pubmed |
| pubmed-article:17065408 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17065408 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17065408 | pubmed:pagination | 249-61 | lld:pubmed |
| pubmed-article:17065408 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:17065408 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17065408 | pubmed:articleTitle | Localization of vascular endothelial growth factor (VEGF) receptors in normal and adenomatous pituitaries: detection of a non-endothelial function of VEGF in pituitary tumours. | lld:pubmed |
| pubmed-article:17065408 | pubmed:affiliation | Max-Planck-Institute of Psychiatry, Neuroendocrinology Group, Kraepelinstr. 10, D-80804 Munich, Germany. onofri@mpipsykl.mpg.de | lld:pubmed |
| pubmed-article:17065408 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17065408 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17065408 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17065408 | lld:pubmed |
