| pubmed-article:17062002 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17062002 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:17062002 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:17062002 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17062002 | lifeskim:mentions | umls-concept:C0025932 | lld:lifeskim |
| pubmed-article:17062002 | lifeskim:mentions | umls-concept:C1135183 | lld:lifeskim |
| pubmed-article:17062002 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17062002 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:17062002 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:17062002 | lifeskim:mentions | umls-concept:C1334114 | lld:lifeskim |
| pubmed-article:17062002 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:17062002 | lifeskim:mentions | umls-concept:C0150312 | lld:lifeskim |
| pubmed-article:17062002 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:17062002 | pubmed:dateCreated | 2007-2-12 | lld:pubmed |
| pubmed-article:17062002 | pubmed:abstractText | Xenotransplantation with porcine thymus is emerging as a possible means to reconstitute host cellular immunity and to induce immune tolerance in rodents and large animals. However, the presence of regulatory T cells (Treg cells) in this model needs to be determined. We herein demonstrated that efficient repopulation of mouse CD4+CD25+Treg cells was achieved in Balb/c nude mice by grafting neonatal porcine thymic tissue (NP THY). Mouse CD4+CD25+T cells expressed normal levels of Foxp3 in NP THY-grafted nude mice. Furthermore, these CD4+CD25+Treg cells showed significant inhibitory effects on the cell proliferation or interleukin-2 products of syngeneic T cells to alloantigens, Con A or a peptide antigen, although the potent immunosuppressive function might be lower than CD4+CD25+Treg cells in Balb/c mice. CD4+CD25+T cells in NP THY-grafted nude mice showed significantly stronger inhibition on the response to donor porcine antigens of CD4+CD25(-)T cells than CD4+CD25+Treg cells in Balb/c mice. Both CD4+CD25+Treg cells in NP THY-grafted nude and Balb/c mice prevented the development of autoimmune disease mediated by syngeneic CD4+CD25(-)T cells in a similar efficient way in the secondary recipients. These findings provide evidence for the potential involvement of CD4+CD25+Treg cells in keeping self-tolerance and transplant tolerance in this xeno-thymus transplantation model. | lld:pubmed |
| pubmed-article:17062002 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17062002 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17062002 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17062002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17062002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17062002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17062002 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17062002 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17062002 | pubmed:issn | 1600-6135 | lld:pubmed |
| pubmed-article:17062002 | pubmed:author | pubmed-author:YuDD | lld:pubmed |
| pubmed-article:17062002 | pubmed:author | pubmed-author:SunLL | lld:pubmed |
| pubmed-article:17062002 | pubmed:author | pubmed-author:WangHH | lld:pubmed |
| pubmed-article:17062002 | pubmed:author | pubmed-author:ZhaiSS | lld:pubmed |
| pubmed-article:17062002 | pubmed:author | pubmed-author:ZhaoLL | lld:pubmed |
| pubmed-article:17062002 | pubmed:author | pubmed-author:SunZZ | lld:pubmed |
| pubmed-article:17062002 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17062002 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:17062002 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17062002 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17062002 | pubmed:pagination | 2841-50 | lld:pubmed |
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| pubmed-article:17062002 | pubmed:meshHeading | pubmed-meshheading:17062002... | lld:pubmed |
| pubmed-article:17062002 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17062002 | pubmed:articleTitle | Presence of functional mouse regulatory CD4+CD25+T cells in xenogeneic neonatal porcine thymus-grafted athymic mice. | lld:pubmed |
| pubmed-article:17062002 | pubmed:affiliation | Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. | lld:pubmed |
| pubmed-article:17062002 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17062002 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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