| pubmed-article:17059818 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17059818 | lifeskim:mentions | umls-concept:C0037929 | lld:lifeskim |
| pubmed-article:17059818 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:17059818 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:17059818 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:17059818 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:17059818 | lifeskim:mentions | umls-concept:C0018447 | lld:lifeskim |
| pubmed-article:17059818 | lifeskim:mentions | umls-concept:C2346753 | lld:lifeskim |
| pubmed-article:17059818 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:17059818 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17059818 | pubmed:dateCreated | 2007-1-30 | lld:pubmed |
| pubmed-article:17059818 | pubmed:abstractText | The amplitude of the H-reflex increases chronically after incomplete SCI and is associated with the development of exaggerated hindlimb reflexes. Although the mechanism for this increased H-reflex is not clear, previous studies have shown that pharmacological activation of the 5-HT2 receptors (5-HT2R) can potentiate the monosynaptic reflex. This study tested the hypothesis that increased expression of 5-HT2R on motoneurons is involved in increased H-reflex amplitude after a standardized clinically relevant contusive SCI. Adult female rats were subjected to contusion, complete surgical transection, or a T8 laminectomy only. At 4 weeks after surgery, H-reflex recordings from the hindpaw plantar muscles of contused rats showed twice the amplitude of that in laminectomy controls or transected rats. To probe the role of 5-HT2R in this increased amplitude, dose-response studies were done with the selective antagonists mianserin or LY53857 and the 5-HT2R agonist (+/-)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI). The drugs were intrathecally infused into the lumbar cord while recording the H-reflex. Mianserin did not have any significant effects on the H-reflex after transection, consistent with the loss of distal serotonergic innervation. After contusion, both 5-HT2R antagonists reduced the H-reflex reflex amplitude with a significantly higher ID50 compared to the uninjured controls. The 5-HT2R agonist DOI significantly increased reflex amplitude in contused but not control rats. Furthermore, while 5-HT immunoreactivity was similar, contused rats displayed increased 5-HT2AR immunoreactivity in plantar muscle motoneurons compared to uninjured controls. We conclude that increased expression of 5-HT2R is likely to be involved in the enhanced H-reflex that develops after contusive SCI. | lld:pubmed |
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| pubmed-article:17059818 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17059818 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17059818 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17059818 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17059818 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17059818 | pubmed:issn | 0014-4886 | lld:pubmed |
| pubmed-article:17059818 | pubmed:author | pubmed-author:LeeJae KJK | lld:pubmed |
| pubmed-article:17059818 | pubmed:author | pubmed-author:WrathallJean... | lld:pubmed |
| pubmed-article:17059818 | pubmed:author | pubmed-author:JohnsonChrist... | lld:pubmed |
| pubmed-article:17059818 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17059818 | pubmed:volume | 203 | lld:pubmed |
| pubmed-article:17059818 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17059818 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17059818 | pubmed:pagination | 502-11 | lld:pubmed |
| pubmed-article:17059818 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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