Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17058242rdf:typepubmed:Citationlld:pubmed
pubmed-article:17058242lifeskim:mentionsumls-concept:C0008976lld:lifeskim
pubmed-article:17058242lifeskim:mentionsumls-concept:C1707455lld:lifeskim
pubmed-article:17058242lifeskim:mentionsumls-concept:C0282440lld:lifeskim
pubmed-article:17058242lifeskim:mentionsumls-concept:C2603343lld:lifeskim
pubmed-article:17058242lifeskim:mentionsumls-concept:C1511545lld:lifeskim
pubmed-article:17058242pubmed:issue5lld:pubmed
pubmed-article:17058242pubmed:dateCreated2006-10-26lld:pubmed
pubmed-article:17058242pubmed:abstractTextObservational analogs of randomized clinical trials (RCTs) are well accepted in the study of disease risk factors, diagnosis, and prognosis. There is controversy about observational studies when the focus is on the intended benefit due to lack of blinding and poor control for unmeasured confounding. Well-designed randomized clinical trials are costly both in time and money. Therefore, existing databases are used increasingly and are often the only feasible source with which to examine delayed health effects. We reviewed the reasons for possible discrepancies between RCTs and observational studies. There can be different patient populations, differences in therapeutic regimen, control of confounding, follow-up, measuring outcome, and differences arising from the intention-to-treat analysis. Observational studies cannot replace trials, nor do trials make observational studies unnecessary. Both designs are susceptible to particular bias, so neither provides perfect information.lld:pubmed
pubmed-article:17058242pubmed:languageenglld:pubmed
pubmed-article:17058242pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17058242pubmed:citationSubsetIMlld:pubmed
pubmed-article:17058242pubmed:statusMEDLINElld:pubmed
pubmed-article:17058242pubmed:monthNovlld:pubmed
pubmed-article:17058242pubmed:issn0270-9139lld:pubmed
pubmed-article:17058242pubmed:authorpubmed-author:RothmanKennet...lld:pubmed
pubmed-article:17058242pubmed:authorpubmed-author:LashTimothy...lld:pubmed
pubmed-article:17058242pubmed:authorpubmed-author:SørensenHenri...lld:pubmed
pubmed-article:17058242pubmed:issnTypePrintlld:pubmed
pubmed-article:17058242pubmed:volume44lld:pubmed
pubmed-article:17058242pubmed:ownerNLMlld:pubmed
pubmed-article:17058242pubmed:authorsCompleteYlld:pubmed
pubmed-article:17058242pubmed:pagination1075-82lld:pubmed
pubmed-article:17058242pubmed:dateRevised2007-11-15lld:pubmed
pubmed-article:17058242pubmed:meshHeadingpubmed-meshheading:17058242...lld:pubmed
pubmed-article:17058242pubmed:meshHeadingpubmed-meshheading:17058242...lld:pubmed
pubmed-article:17058242pubmed:meshHeadingpubmed-meshheading:17058242...lld:pubmed
pubmed-article:17058242pubmed:meshHeadingpubmed-meshheading:17058242...lld:pubmed
pubmed-article:17058242pubmed:year2006lld:pubmed
pubmed-article:17058242pubmed:articleTitleBeyond randomized controlled trials: a critical comparison of trials with nonrandomized studies.lld:pubmed
pubmed-article:17058242pubmed:affiliationDepartment of Clinical Epidemiology, Aarhus University Hospital, 8000 Aarhus C, Denmark. hts@dce.au.dklld:pubmed
pubmed-article:17058242pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17058242pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:17058242pubmed:publicationTypeReviewlld:pubmed
pubmed-article:17058242pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17058242lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17058242lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17058242lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17058242lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17058242lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17058242lld:pubmed