| pubmed-article:17056585 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17056585 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:17056585 | lifeskim:mentions | umls-concept:C0278883 | lld:lifeskim |
| pubmed-article:17056585 | lifeskim:mentions | umls-concept:C2243049 | lld:lifeskim |
| pubmed-article:17056585 | lifeskim:mentions | umls-concept:C0376518 | lld:lifeskim |
| pubmed-article:17056585 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:17056585 | pubmed:dateCreated | 2006-10-23 | lld:pubmed |
| pubmed-article:17056585 | pubmed:abstractText | Cancer vaccines can induce the in vivo generation of tumor Ag-specific T cells in patients with metastatic melanoma yet seldom elicit objective clinical responses. Alternatively, adoptive transfer of autologous tumor-infiltrating lymphocytes (TIL) can mediate tumor regression in 50% of lymphodepleted patients, but are logistically and technically difficult to generate. In this study, we evaluated the capability of vaccine-induced PBMC to mediate tumor regression after transfer to patients receiving the same chemotherapy-induced lymphodepletion used for TIL transfer therapy. Autologous PBMC from nine gp100-vaccinated patients with metastatic melanoma were stimulated ex vivo with the gp100:209-217(210M) peptide and transferred in combination with high-dose IL-2 and cancer vaccine. Transferred PBMC contained highly avid, gp100:209-217 peptide-reactive CD8(+) T cells. One week after transfer, lymphocyte counts peaked (median of 14.3 x 10(3) cells//microl; range of 0.9-59.7 x 10(3) cells/microl), with 56% of patients experiencing a lymphocytosis. gp100:209-217 peptide-specific CD8(+) T cells persisted at high levels in the blood of all patients and demonstrated significant tumor-specific IFN-gamma secretion in vitro. Melanocyte-directed autoimmunity was noted in two patients; however, no patient experienced an objective clinical response. These studies demonstrate the feasibility and safety of using vaccine-induced PBMC for cell transfer, but suggests that they are not as effective as TIL in adoptive immunotherapy even when transferred into lymphodepleted hosts. | lld:pubmed |
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| pubmed-article:17056585 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17056585 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17056585 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:17056585 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17056585 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17056585 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:17056585 | pubmed:author | pubmed-author:RosenbergStev... | lld:pubmed |
| pubmed-article:17056585 | pubmed:author | pubmed-author:DudleyMark... | lld:pubmed |
| pubmed-article:17056585 | pubmed:author | pubmed-author:WunderlichJoh... | lld:pubmed |
| pubmed-article:17056585 | pubmed:author | pubmed-author:PowellDaniel... | lld:pubmed |
| pubmed-article:17056585 | pubmed:author | pubmed-author:HoganKatherin... | lld:pubmed |
| pubmed-article:17056585 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17056585 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17056585 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:17056585 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17056585 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17056585 | pubmed:pagination | 6527-39 | lld:pubmed |
| pubmed-article:17056585 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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