Linked Life Data

17055455

Source:http://linkedlifedata.com/resource/pubmed/id/17055455

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17055455rdf:typepubmed:Citationlld:pubmed
pubmed-article:17055455lifeskim:mentionsumls-concept:C0007600lld:lifeskim
pubmed-article:17055455lifeskim:mentionsumls-concept:C0032098lld:lifeskim
pubmed-article:17055455lifeskim:mentionsumls-concept:C0600139lld:lifeskim
pubmed-article:17055455lifeskim:mentionsumls-concept:C0007595lld:lifeskim
pubmed-article:17055455lifeskim:mentionsumls-concept:C1518174lld:lifeskim
pubmed-article:17055455lifeskim:mentionsumls-concept:C0034786lld:lifeskim
pubmed-article:17055455lifeskim:mentionsumls-concept:C1514762lld:lifeskim
pubmed-article:17055455lifeskim:mentionsumls-concept:C1441547lld:lifeskim
pubmed-article:17055455lifeskim:mentionsumls-concept:C1881795lld:lifeskim
pubmed-article:17055455lifeskim:mentionsumls-concept:C0205296lld:lifeskim
pubmed-article:17055455lifeskim:mentionsumls-concept:C0053508lld:lifeskim
pubmed-article:17055455pubmed:issue1lld:pubmed
pubmed-article:17055455pubmed:dateCreated2006-10-31lld:pubmed
pubmed-article:17055455pubmed:abstractTextHinokitiol (beta-thujaplicin), a troplone-related compound found in the heartwood of cupressaceous plants, strongly inhibits the proliferation of a broad range of tumor cell lines. This is the first report to demonstrate that hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts AR signaling in prostate carcinoma cell lines. Our present studies indicate that hinokitiol suppresses androgen/AR-mediated cell growth and androgen-stimulated DNA synthesis by [(3)H]thymidine incorporation in a dose- and time-dependent manner. Hinokitiol simultaneously suppresses the intracellular and secreted PSA levels, a marker for the progression of prostate cancer. Hinokitiol significantly represses the AR mRNA and protein expression in a dose- and time-dependent manner. Additionally, the ligand-binding assay shows that hinokitiol blocks binding of the synthetic androgen [(3)H]R1881 to AR in LNCaP cells. These findings collectively suggest that hinokitiol is potentially effective against prostate cancer in vitro, and thus it might become a novel chemopreventive or chemotherapeutic agent for prostate cancer.lld:pubmed
pubmed-article:17055455pubmed:languageenglld:pubmed
pubmed-article:17055455pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17055455pubmed:citationSubsetIMlld:pubmed
pubmed-article:17055455pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17055455pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17055455pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17055455pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17055455pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17055455pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17055455pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17055455pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17055455pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17055455pubmed:statusMEDLINElld:pubmed
pubmed-article:17055455pubmed:monthDeclld:pubmed
pubmed-article:17055455pubmed:issn0006-291Xlld:pubmed
pubmed-article:17055455pubmed:authorpubmed-author:YamauchiHitos...lld:pubmed
pubmed-article:17055455pubmed:authorpubmed-author:LiuShichengSlld:pubmed
pubmed-article:17055455pubmed:issnTypePrintlld:pubmed
pubmed-article:17055455pubmed:day8lld:pubmed
pubmed-article:17055455pubmed:volume351lld:pubmed
pubmed-article:17055455pubmed:ownerNLMlld:pubmed
pubmed-article:17055455pubmed:authorsCompleteYlld:pubmed
pubmed-article:17055455pubmed:pagination26-32lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:meshHeadingpubmed-meshheading:17055455...lld:pubmed
pubmed-article:17055455pubmed:year2006lld:pubmed
pubmed-article:17055455pubmed:articleTitleHinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell lines.lld:pubmed
pubmed-article:17055455pubmed:affiliationResearch Department, Saitama Daiichi Pharmaceutical Co., Ltd., 8-1, Minamisakae-cho, Kasukabe, Saitama 344-0057, Japan. riu@sdsk.co.jplld:pubmed
pubmed-article:17055455pubmed:publicationTypeJournal Articlelld:pubmed
entrez-gene:367entrezgene:pubmedpubmed-article:17055455lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:17055455lld:entrezgene
lhgdn:association:34034lhgdn:found_inpubmed-article:17055455lld:lhgdn