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pubmed-article:17055306pubmed:abstractTextCartilage destruction in osteoarthritis (OA) involves the excessive degradation and increased synthesis of cartilage matrix macromolecules including type II collagen (CII) and proteoglycans. The lack of osteophytes (atrophic form of OA) has been shown to be a disease severity factor in hip OA. Since osteophyte formation involves endochondral ossification and a cartilage intermediate, atrophic OA may also exhibit differences in cartilage turnover compared to hypertrophic OA. Cartilage serum biomarkers may offer an opportunity to identify such differences in patients.lld:pubmed
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pubmed-article:17055306pubmed:articleTitleDifferences in biomarkers of type II collagen in atrophic and hypertrophic osteoarthritis of the hip: implications for the differing pathobiologies.lld:pubmed
pubmed-article:17055306pubmed:affiliationDepartment of Rheumatology, University Hospital Lyon-sud, Lyon, France. thierry.conrozier@chu-lyon.frlld:pubmed
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