| pubmed-article:17052189 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17052189 | lifeskim:mentions | umls-concept:C0023689 | lld:lifeskim |
| pubmed-article:17052189 | lifeskim:mentions | umls-concept:C0041538 | lld:lifeskim |
| pubmed-article:17052189 | pubmed:issue | Pt 5 | lld:pubmed |
| pubmed-article:17052189 | pubmed:dateCreated | 2006-10-20 | lld:pubmed |
| pubmed-article:17052189 | pubmed:abstractText | Mutations in the parkin gene are a common cause of autosomal recessive early-onset parkinsonism. Parkin functions as an E3 ubiquitin ligase where it can polyubiquitinate a number of its protein substrates, thus targeting them for degradation by the 26 S proteasomal complex. Recent studies have demonstrated that alternative modes of parkin-mediated ubiquitination may serve other non-degradative regulatory roles. In addition, parkin appears to function as a multipurpose neuroprotectant in a number of toxic paradigms. Coupled with these observations, parkin may integrate other gene products associated with parkinsonism, including alpha-synuclein, LRRK2 (leucine-rich repeat kinase 2), DJ-1 and PINK1 [PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced putative kinase 1], into a common biochemical pathway of potential relevance to disease pathogenesis. Parkin therefore represents a unique multifaceted ubiquitin ligase consistent with an important housekeeping role in maintaining the integrity or survival of dopaminergic neurons. | lld:pubmed |
| pubmed-article:17052189 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17052189 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17052189 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17052189 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17052189 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17052189 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17052189 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17052189 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17052189 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17052189 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17052189 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17052189 | pubmed:issn | 0300-5127 | lld:pubmed |
| pubmed-article:17052189 | pubmed:author | pubmed-author:MooreD JDJ | lld:pubmed |
| pubmed-article:17052189 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17052189 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:17052189 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17052189 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17052189 | pubmed:pagination | 749-53 | lld:pubmed |
| pubmed-article:17052189 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:17052189 | pubmed:meshHeading | pubmed-meshheading:17052189... | lld:pubmed |
| pubmed-article:17052189 | pubmed:meshHeading | pubmed-meshheading:17052189... | lld:pubmed |
| pubmed-article:17052189 | pubmed:meshHeading | pubmed-meshheading:17052189... | lld:pubmed |
| pubmed-article:17052189 | pubmed:meshHeading | pubmed-meshheading:17052189... | lld:pubmed |
| pubmed-article:17052189 | pubmed:meshHeading | pubmed-meshheading:17052189... | lld:pubmed |
| pubmed-article:17052189 | pubmed:meshHeading | pubmed-meshheading:17052189... | lld:pubmed |
| pubmed-article:17052189 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17052189 | pubmed:articleTitle | Parkin: a multifaceted ubiquitin ligase. | lld:pubmed |
| pubmed-article:17052189 | pubmed:affiliation | Institute for Cell Engineering and Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, Broadway Research Building, Suite 731, Baltimore, MD 21205, USA. dmoore20@jhmi.edu | lld:pubmed |
| pubmed-article:17052189 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17052189 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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