| pubmed-article:17046693 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17046693 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:17046693 | lifeskim:mentions | umls-concept:C0072899 | lld:lifeskim |
| pubmed-article:17046693 | lifeskim:mentions | umls-concept:C1179132 | lld:lifeskim |
| pubmed-article:17046693 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:17046693 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17046693 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17046693 | pubmed:dateCreated | 2006-10-18 | lld:pubmed |
| pubmed-article:17046693 | pubmed:abstractText | Trafficking of AMPA receptors (AMPA-Rs) to and from synapses controls the strength of excitatory synaptic transmission. However, proteins that cluster AMPA-Rs at synapses remain poorly understood. Here we show that PSD-95-like membrane-associated guanylate kinases (PSD-MAGUKs) mediate this synaptic targeting, and we uncover a remarkable functional redundancy within this protein family. By manipulating endogenous neuronal PSD-MAGUK levels, we find that both PSD-95 and PSD-93 independently mediate AMPA-R targeting at mature synapses. We also reveal unanticipated synapse heterogeneity as loss of either PSD-95 or PSD-93 silences largely nonoverlapping populations of excitatory synapses. In adult PSD-95 and PSD-93 double knockout animals, SAP-102 is upregulated and compensates for the loss of synaptic AMPA-Rs. At immature synapses, PSD-95 and PSD-93 play little role in synaptic AMPA-R clustering; instead, SAP-102 dominates. These studies establish a PSD-MAGUK-specific regulation of AMPA-R synaptic expression that establishes and maintains glutamatergic synaptic transmission in the mammalian central nervous system. | lld:pubmed |
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| pubmed-article:17046693 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17046693 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046693 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17046693 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17046693 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17046693 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17046693 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:17046693 | pubmed:author | pubmed-author:NicollRoger... | lld:pubmed |
| pubmed-article:17046693 | pubmed:author | pubmed-author:SteinValentin... | lld:pubmed |
| pubmed-article:17046693 | pubmed:author | pubmed-author:BredtDavid... | lld:pubmed |
| pubmed-article:17046693 | pubmed:author | pubmed-author:FunkeLarsL | lld:pubmed |
| pubmed-article:17046693 | pubmed:author | pubmed-author:EliasGuillerm... | lld:pubmed |
| pubmed-article:17046693 | pubmed:author | pubmed-author:GrantSeth GSG | lld:pubmed |
| pubmed-article:17046693 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17046693 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:17046693 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:17046693 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17046693 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17046693 | pubmed:pagination | 307-20 | lld:pubmed |
| pubmed-article:17046693 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:17046693 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17046693 | pubmed:articleTitle | Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins. | lld:pubmed |
| pubmed-article:17046693 | pubmed:affiliation | Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA. | lld:pubmed |
| pubmed-article:17046693 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17046693 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17046693 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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