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pubmed-article:17043848pubmed:abstractTextDrug dosing during continuous venovenous hemofiltration (CVVH) is based partly upon the CVVH clearance (Cl(CVVH)) of the drug. Cl(CVVH) is the product of the sieving coefficient (SC) and ultrafiltration rate (Q(uf)). Although it has been suggested that the SC can be replaced by the fraction of a drug not bound to protein (F(up)), the F(up) values as reported in the literature may not reflect the protein binding in critically ill patients with renal failure. We compared the observed Cl(CVVH) (SC x Q(uf)) with the estimated Cl(CVVH) (estimated F(UP) x Q(uf)) and determined the effect on the maintenance dose multiplication factor (MDMF).lld:pubmed
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pubmed-article:17043848pubmed:articleTitleDiscrepancies between observed and predicted continuous venovenous hemofiltration removal of antimicrobial agents in critically ill patients and the effects on dosing.lld:pubmed
pubmed-article:17043848pubmed:affiliationDepartment of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. c.s.bouman@amc.uva.nllld:pubmed
pubmed-article:17043848pubmed:publicationTypeJournal Articlelld:pubmed