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pubmed-article:17040995pubmed:abstractTextChronic renal insufficiency is associated with the retention of solutes normally excreted by healthy kidneys. P-cresol, a prototype protein-bound uraemic retention solute, has been shown to exert toxic effects in vitro. Recently, however, it has been demonstrated that p-cresol in the human body is conjugated, with p-cresylsulphate as the main metabolite.lld:pubmed
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pubmed-article:17040995pubmed:articleTitleP-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production.lld:pubmed
pubmed-article:17040995pubmed:affiliationRenal Division, Department of Internal Medicine, University Hospital, De Pintelaan 185, 9000 Gent, Belgium.lld:pubmed
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