| pubmed-article:1704030 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1704030 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1704030 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:1704030 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:1704030 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1704030 | lifeskim:mentions | umls-concept:C1519726 | lld:lifeskim |
| pubmed-article:1704030 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1704030 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1704030 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1704030 | pubmed:dateCreated | 1991-3-8 | lld:pubmed |
| pubmed-article:1704030 | pubmed:abstractText | Recent evidence suggests that the zeta-subunit of the TCR complex plays a critical role in transducing signals initiated by the Ag receptor heterodimer. Because thymic maturation involves specific interactions between the TCR complex and thymic stromal cells, the zeta-subunit has been postulated to also play a role in this process. To assess the potential for zeta to contribute to thymocyte maturation, we have used an anti-zeta mAb (TIA-2) to quantitate its expression in mature (CD3bright) and immature (CD3dim and CD3-) populations of human thymocytes. Using both flow cytometric and immunoblotting analysis, we found that the relative expression of TCR-zeta varied directly with the surface expression of CD3. Importantly, TCR-zeta was detected in the majority of CD3- thymocytes, indicating that its expression precedes the surface appearance of CD3:TCR. In thymocytes, TCR-zeta was found to be constitutively phosphorylated on tyrosine residues. The relative expression of phospho-zeta varied directly with the maturational stage of the thymocyte, with the mature (CD3bright), single positive cells accounting for most of the phospho-zeta found in the human thymus. The expression of phospho-zeta could be significantly increased by activating thymocytes with mAb reactive with either CD3 or CD2. These results suggest that TCR-zeta is functionally linked to the major thymocyte activation receptors. | lld:pubmed |
| pubmed-article:1704030 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1704030 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1704030 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1704030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1704030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1704030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1704030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1704030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1704030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1704030 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1704030 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1704030 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1704030 | pubmed:author | pubmed-author:SchlossmanS... | lld:pubmed |
| pubmed-article:1704030 | pubmed:author | pubmed-author:MorioSS | lld:pubmed |
| pubmed-article:1704030 | pubmed:author | pubmed-author:AndersonPP | lld:pubmed |
| pubmed-article:1704030 | pubmed:author | pubmed-author:BlueM LML | lld:pubmed |
| pubmed-article:1704030 | pubmed:author | pubmed-author:VivierEE | lld:pubmed |
| pubmed-article:1704030 | pubmed:author | pubmed-author:DaleyJJ | lld:pubmed |
| pubmed-article:1704030 | pubmed:author | pubmed-author:TianQ SQS | lld:pubmed |
| pubmed-article:1704030 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1704030 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1704030 | pubmed:volume | 146 | lld:pubmed |
| pubmed-article:1704030 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1704030 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1704030 | pubmed:pagination | 1142-8 | lld:pubmed |
| pubmed-article:1704030 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1704030 | pubmed:meshHeading | pubmed-meshheading:1704030-... | lld:pubmed |
| pubmed-article:1704030 | pubmed:meshHeading | pubmed-meshheading:1704030-... | lld:pubmed |
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| pubmed-article:1704030 | pubmed:meshHeading | pubmed-meshheading:1704030-... | lld:pubmed |
| pubmed-article:1704030 | pubmed:meshHeading | pubmed-meshheading:1704030-... | lld:pubmed |
| pubmed-article:1704030 | pubmed:meshHeading | pubmed-meshheading:1704030-... | lld:pubmed |
| pubmed-article:1704030 | pubmed:meshHeading | pubmed-meshheading:1704030-... | lld:pubmed |
| pubmed-article:1704030 | pubmed:meshHeading | pubmed-meshheading:1704030-... | lld:pubmed |
| pubmed-article:1704030 | pubmed:meshHeading | pubmed-meshheading:1704030-... | lld:pubmed |
| pubmed-article:1704030 | pubmed:meshHeading | pubmed-meshheading:1704030-... | lld:pubmed |
| pubmed-article:1704030 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1704030 | pubmed:articleTitle | Expression and tyrosine phosphorylation of the T cell receptor zeta-subunit in human thymocytes. | lld:pubmed |
| pubmed-article:1704030 | pubmed:affiliation | Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115. | lld:pubmed |
| pubmed-article:1704030 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1704030 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1704030 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1704030 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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