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pubmed-article:1703881pubmed:abstractTextNeonatal alloimmune thrombocytopenia (NAIT) is caused by maternal immunization against fetal platelet antigens. In the serum of a mother who gave birth to a child with the typical clinical picture of NAIT we found an antibody directed against the new platelet antigen Sra. Anti-Sra was found to react in the immunofluorescence test and in a glycoprotein (GP) specific immunoassay (MAIPA) using a monoclonal antibody against GP IIb/IIIa for antigen immobilization with the child's and father's platelets. Radioimmunoprecipitation and immunoblot allowed to assign the Sra-antigen to GP IIIa. The phenotype frequency was estimated less than 1%, characterising the Sra-antigen as the first 'private' alloantigen on platelets.lld:pubmed
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pubmed-article:1703881pubmed:pagination389-91lld:pubmed
pubmed-article:1703881pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:1703881pubmed:articleTitle[Sr(a), a "private" thrombocyte alloantigen as a cause of neonatal alloimmune thrombocytopenia].lld:pubmed
pubmed-article:1703881pubmed:affiliationInstitut für Klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität Giessen.lld:pubmed
pubmed-article:1703881pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1703881pubmed:publicationTypeEnglish Abstractlld:pubmed