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pubmed-article:17035952pubmed:abstractTextUsing data from families in which marker genotypes are known for the father, the mother and the affected offspring, a simple statistic for testing for imprinting effects is developed. The statistic considers whether the expected number of families in which the father carries more copies of a particular marker allele than the mother is equal to the expected number of families in which the mother carries more copies of the allele than the father. The proposed parent-of-origin effects test statistic (POET) is shown to be normally distributed and can be employed to test for imprinting in situations where the marker locus need not be a disease susceptibility locus and where the female and male recombination fractions are sex-specific. A simulation study is conducted to characterize the power of the POET and other properties, and its results show that it is appropriate to employ the POET.lld:pubmed
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pubmed-article:17035952pubmed:authorpubmed-author:ZhouJ-YJYlld:pubmed
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pubmed-article:17035952pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:17035952pubmed:year2007lld:pubmed
pubmed-article:17035952pubmed:articleTitleA simple method for detection of imprinting effects based on case-parents trios.lld:pubmed
pubmed-article:17035952pubmed:affiliationDepartment of Statistics and Actuarial Science, The University of Hong Kong, Hong Kong, China.lld:pubmed
pubmed-article:17035952pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17035952pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:17035952pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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