pubmed-article:17034766 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17034766 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
pubmed-article:17034766 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:17034766 | lifeskim:mentions | umls-concept:C0009170 | lld:lifeskim |
pubmed-article:17034766 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
pubmed-article:17034766 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
pubmed-article:17034766 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:17034766 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
pubmed-article:17034766 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
pubmed-article:17034766 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
pubmed-article:17034766 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
pubmed-article:17034766 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:17034766 | pubmed:dateCreated | 2006-11-27 | lld:pubmed |
pubmed-article:17034766 | pubmed:abstractText | The US is experiencing an epidemic of cocaine use entangled with HIV-1 infection. Normal human astrocytes (NHA) are susceptible to HIV-1 infection. We utilized LTR-R/U5 amplification, p24 antigen assay and the proteomic method of difference gel electrophoresis (DIGE) combined with protein identification through HPLC-MS/MS to investigate the effect of cocaine on HIV-1 infectivity and the proteomic profile of NHA, respectively. Data demonstrate that cocaine significantly upregulates HIV-1 infection in NHA as measured by LTR-R/U5 amplification and p24 antigen assay. Further, our results show for the first time that cocaine differentially regulates the expression of a number of proteins by NHA that may play a role in the neuropathogenesis of HIV-1 disease. | lld:pubmed |
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pubmed-article:17034766 | pubmed:language | eng | lld:pubmed |
pubmed-article:17034766 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17034766 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:17034766 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:17034766 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17034766 | pubmed:month | Dec | lld:pubmed |
pubmed-article:17034766 | pubmed:issn | 0006-8993 | lld:pubmed |
pubmed-article:17034766 | pubmed:author | pubmed-author:SchwartzStanl... | lld:pubmed |
pubmed-article:17034766 | pubmed:author | pubmed-author:MahajanSupriy... | lld:pubmed |
pubmed-article:17034766 | pubmed:author | pubmed-author:NairMadhavan... | lld:pubmed |
pubmed-article:17034766 | pubmed:author | pubmed-author:ReynoldsJessi... | lld:pubmed |
pubmed-article:17034766 | pubmed:author | pubmed-author:BindukumarBB | lld:pubmed |
pubmed-article:17034766 | pubmed:author | pubmed-author:SykesDonaldD | lld:pubmed |
pubmed-article:17034766 | pubmed:issnType | Print | lld:pubmed |