| pubmed-article:17032926 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17032926 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:17032926 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:17032926 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:17032926 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:17032926 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:17032926 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17032926 | pubmed:dateCreated | 2007-2-7 | lld:pubmed |
| pubmed-article:17032926 | pubmed:abstractText | A temporal decline in tissue stem cell functionality may be a key component of mammalian aging. The tumor suppressor p53 has recently been implicated as a potential regulator of aging. We examined age-associated hematopoietic stem cell (HSC) dynamics in mice with varying p53 activities. Reduced p53 activity in p53+/- mice was associated with higher numbers of proliferating hematopoietic stem and progenitor cells in old age compared with aged wild-type (p53+/+) mice. We also assessed HSC dynamics in a p53 mutant mouse model (p53+/m) with higher apparent p53 activity than wild-type mice. The p53 hypermorphic (p53+/m) mice display phenotypes of premature aging. Many aged p53+/m organs exhibit reduced cellularity and atrophy, suggesting defects in stem-cell regenerative capacity. HSC numbers from old p53+/m mice fail to increase with age, unlike those of their p53+/+ and p53+/- counterparts. Moreover, transplantation of 500 HSCs from old p53+/m mice into lethally irradiated recipients resulted in reduced engraftment compared with old wild-type p53+/+ and p53+/- HSCs. Thus, alteration of p53 activity affects stem-cell numbers, proliferation potential, and hematopoiesis in older organisms, supporting a model in which aging is caused in part by a decline in tissue stem cell regenerative function. | lld:pubmed |
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| pubmed-article:17032926 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17032926 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17032926 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17032926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17032926 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17032926 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17032926 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:17032926 | pubmed:author | pubmed-author:DonehowerLawr... | lld:pubmed |
| pubmed-article:17032926 | pubmed:author | pubmed-author:GoodellMargar... | lld:pubmed |
| pubmed-article:17032926 | pubmed:author | pubmed-author:GeigerHartmut... | lld:pubmed |
| pubmed-article:17032926 | pubmed:author | pubmed-author:Van ZantGaryG | lld:pubmed |
| pubmed-article:17032926 | pubmed:author | pubmed-author:MooreLynetteL | lld:pubmed |
| pubmed-article:17032926 | pubmed:author | pubmed-author:ChambersStuar... | lld:pubmed |
| pubmed-article:17032926 | pubmed:author | pubmed-author:DumbleMelissa... | lld:pubmed |
| pubmed-article:17032926 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17032926 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17032926 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:17032926 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17032926 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17032926 | pubmed:pagination | 1736-42 | lld:pubmed |
| pubmed-article:17032926 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17032926 | pubmed:meshHeading | pubmed-meshheading:17032926... | lld:pubmed |
| pubmed-article:17032926 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17032926 | pubmed:articleTitle | The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. | lld:pubmed |
| pubmed-article:17032926 | pubmed:affiliation | Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, and Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, OH, USA. | lld:pubmed |
| pubmed-article:17032926 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17032926 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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