| pubmed-article:17031404 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17031404 | lifeskim:mentions | umls-concept:C1335110 | lld:lifeskim |
| pubmed-article:17031404 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:17031404 | lifeskim:mentions | umls-concept:C2698872 | lld:lifeskim |
| pubmed-article:17031404 | lifeskim:mentions | umls-concept:C2347610 | lld:lifeskim |
| pubmed-article:17031404 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:17031404 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:17031404 | pubmed:dateCreated | 2006-11-14 | lld:pubmed |
| pubmed-article:17031404 | pubmed:abstractText | The -1p/-19q genotype predicts chemosensitivity in oligodendroglial neoplasms, but some with intact 1p/19q also respond and not all with 1p/19q loss derive durable benefit from chemotherapy. We have evaluated the predictive and prognostic significance of pretherapy (201)Tl and (18)F-FDG SPECT and genotype in 38 primary and 10 recurrent oligodendroglial neoplasms following PCV chemotherapy. 1p/19q loss was seen in 8/15 OII, 6/15 OAII, 7/7 OIII, 3/11 OAIII and was associated with response (Fisher-Exact: P=0.000) and prolonged progression-free (log-rank: P=0.002) and overall survival (OS) (log-rank: P=0.0048). Response was unrelated to metabolism, with tumours with high or low metabolism showing response. Increased (18)F-FDG or (201)Tl uptake predicted shorter progression-free survival (PFS) in the series (log-rank: (201)Tl P=0.0097, (18)F-FDG P=0.0170) and in cases with or without the -1p/-19q genotype. Elevated metabolism was associated with shorter OS in cases with intact 1p/19q (log-rank: (18)F-FDG P=0.0077; (201)Tl P=0.0004) and shorter PFS in responders (log-rank: (18)F-FDG P=0.005; (201)Tl P=0.0132). (201)Tl uptake and 1p/19q loss were independent predictors of survival in multivariate analysis. In this initial study, (201)Tl and (18)F-FDG uptake did not predict response to PCV, but may be associated with poor survival following therapy irrespective of genotype. This may be clinically useful warranting further study. | lld:pubmed |
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| pubmed-article:17031404 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17031404 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17031404 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17031404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17031404 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17031404 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17031404 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:SmithTT | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:WalkerCC | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:ProsserJJ | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:WarnkeP CPC | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:JoyceK AKA | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:BroomeJJ | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:HusbandDD | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:HaylockBB | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:JenkinsonM... | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:VinjamuriSS | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:KopitzkiKK | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:du PlessisD... | lld:pubmed |
| pubmed-article:17031404 | pubmed:author | pubmed-author:FildesDD | lld:pubmed |
| pubmed-article:17031404 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17031404 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:17031404 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:17031404 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17031404 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17031404 | pubmed:pagination | 1424-31 | lld:pubmed |
| pubmed-article:17031404 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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