| pubmed-article:17030951 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17030951 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:17030951 | lifeskim:mentions | umls-concept:C0247771 | lld:lifeskim |
| pubmed-article:17030951 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:17030951 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:17030951 | lifeskim:mentions | umls-concept:C2699488 | lld:lifeskim |
| pubmed-article:17030951 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:17030951 | pubmed:dateCreated | 2006-10-31 | lld:pubmed |
| pubmed-article:17030951 | pubmed:abstractText | A defining characteristic of persistent viral infections is the loss and functional inactivation of antiviral effector T cells, which prevents viral clearance. Interleukin-10 (IL-10) suppresses cellular immune responses by modulating the function of T cells and antigen-presenting cells. In this paper, we report that IL-10 production is drastically increased in mice persistently infected with lymphocytic choriomeningitis virus. In vivo blockade of the IL-10 receptor (IL-10R) with a neutralizing antibody resulted in rapid resolution of the persistent infection. IL-10 secretion was diminished and interferon gamma production by antiviral CD8+ T cells was enhanced. In persistently infected mice, CD8alpha+ dendritic cell (DC) numbers declined early after infection, whereas CD8alpha- DC numbers were not affected. CD8alpha- DCs supported IL-10 production and subsequent dampening of antiviral T cell responses. Therapeutic IL-10R blockade broke the cycle of IL-10-mediated immune suppression, preventing IL-10 priming by CD8alpha- DCs and enhancing antiviral responses and thereby resolving infection without causing immunopathology. | lld:pubmed |
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| pubmed-article:17030951 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17030951 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17030951 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17030951 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17030951 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17030951 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:17030951 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:17030951 | pubmed:author | pubmed-author:CrottyShaneS | lld:pubmed |
| pubmed-article:17030951 | pubmed:author | pubmed-author:MartinicMaria... | lld:pubmed |
| pubmed-article:17030951 | pubmed:author | pubmed-author:LingEleanor... | lld:pubmed |
| pubmed-article:17030951 | pubmed:author | pubmed-author:EjrnaesMetteM | lld:pubmed |
| pubmed-article:17030951 | pubmed:author | pubmed-author:FilippiChrist... | lld:pubmed |
| pubmed-article:17030951 | pubmed:author | pubmed-author:TogherLisa... | lld:pubmed |
| pubmed-article:17030951 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17030951 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:17030951 | pubmed:volume | 203 | lld:pubmed |
| pubmed-article:17030951 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17030951 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17030951 | pubmed:pagination | 2461-72 | lld:pubmed |
| pubmed-article:17030951 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17030951 | pubmed:meshHeading | pubmed-meshheading:17030951... | lld:pubmed |
| pubmed-article:17030951 | pubmed:meshHeading | pubmed-meshheading:17030951... | lld:pubmed |
| pubmed-article:17030951 | pubmed:meshHeading | pubmed-meshheading:17030951... | lld:pubmed |
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| pubmed-article:17030951 | pubmed:meshHeading | pubmed-meshheading:17030951... | lld:pubmed |
