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pubmed-article:17027991pubmed:abstractTextThe effects of chronic electroconvulsive shock (ECS), given daily for 1, 5 and 10 days, on the activation of extracellular signal-regulated kinase (ERK) were studied in the rat frontal cortex. The phosphorylation of MEK1/2 and ERK1/2 increased through 5 days of ECS. Thereafter, a plateau was achieved. The expression of brain-derived neurotrophic factor was continuously increased for 10 days. Our data show that the effect of ECS on ERK1/2 signaling is increased with chronic treatment.lld:pubmed
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pubmed-article:17027991pubmed:authorpubmed-author:KangUng GuUGlld:pubmed
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pubmed-article:17027991pubmed:articleTitleActivation of extracellular signal-regulated kinase signaling by chronic electroconvulsive shock in the rat frontal cortex.lld:pubmed
pubmed-article:17027991pubmed:affiliationDepartment of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, and Institute of Human Behavioral Medicine, Seoul National University, Seoul, Korea.lld:pubmed
pubmed-article:17027991pubmed:publicationTypeJournal Articlelld:pubmed
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