| pubmed-article:1701568 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1701568 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:1701568 | lifeskim:mentions | umls-concept:C0282519 | lld:lifeskim |
| pubmed-article:1701568 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1701568 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:1701568 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1701568 | pubmed:issue | 4986 | lld:pubmed |
| pubmed-article:1701568 | pubmed:dateCreated | 1991-1-22 | lld:pubmed |
| pubmed-article:1701568 | pubmed:abstractText | A series of dipyridodiazepinones have been shown to be potent inhibitors of human immunodeficiency virus-1 (HIV-1) reverse transcriptase (RT). One compound, BI-RG-587, had a Ki of 200 nanomolar for inhibition of HIV-1 RT that was noncompetitive with respect to deoxyguanosine triphosphate. BI-RG-587 was specific for HIV-1 RT, having no effect on feline and simian RT or any mammalian DNA polymerases. BI-RG-587 inhibited HIV-1 replication in vitro as demonstrated by in situ hybridization, inhibition of protein p24 production, and the lack of syncytia formation in cultured human T cell lines and freshly isolated human peripheral blood lymphocytes. Cytotoxicity studies of BI-RG-587 on human cells showed a high therapeutic index (greater than 8000) in culture. | lld:pubmed |
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| pubmed-article:1701568 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1701568 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1701568 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1701568 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1701568 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:1701568 | pubmed:author | pubmed-author:AdamsJJ | lld:pubmed |
| pubmed-article:1701568 | pubmed:author | pubmed-author:ShihC KCK | lld:pubmed |
| pubmed-article:1701568 | pubmed:author | pubmed-author:MerluzziV JVJ | lld:pubmed |
| pubmed-article:1701568 | pubmed:author | pubmed-author:WuJ CJC | lld:pubmed |
| pubmed-article:1701568 | pubmed:author | pubmed-author:HargraveK DKD | lld:pubmed |
| pubmed-article:1701568 | pubmed:author | pubmed-author:SkoogMM | lld:pubmed |
| pubmed-article:1701568 | pubmed:author | pubmed-author:HattoxSS | lld:pubmed |
| pubmed-article:1701568 | pubmed:author | pubmed-author:GrozingerKK | lld:pubmed |
| pubmed-article:1701568 | pubmed:author | pubmed-author:EcknerKK | lld:pubmed |
| pubmed-article:1701568 | pubmed:author | pubmed-author:LabadiaMM | lld:pubmed |
| pubmed-article:1701568 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1701568 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:1701568 | pubmed:volume | 250 | lld:pubmed |
| pubmed-article:1701568 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1701568 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:1701568 | pubmed:pagination | 1411-3 | lld:pubmed |
| pubmed-article:1701568 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1701568 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1701568 | pubmed:articleTitle | Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor. | lld:pubmed |
| pubmed-article:1701568 | pubmed:affiliation | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877. | lld:pubmed |
| pubmed-article:1701568 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1701568 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1701568 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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