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pubmed-article:1701449pubmed:abstractTextB-cells that express monoclonal IgM anti-MAG antibodies (M-protein) in a patient with neuropathy and non-malignant IgM monoclonal gammopathy were studied by flow cytometry to determine if they bear the CD5 cell surface antigen. The CD5+ antigen is expressed on a subpopulation of B-cells which has been implicated in the secretion of autoantibodies and development of B-cell chronic lymphocytic leukemia (B-CLL). The monoclonal anti-MAG antibodies secreting B-cells were identified by a mouse monoclonal antibody to M-protein idiotype. Cytofluorometric analysis revealed that approximately 62% of the idiotype-positive B-lymphocytes expressed the CD5 antigen. The result of this study indicate that monoclonal anti-MAG antibodies may be secreted by CD5+ B-cells, and that B-cells in some cases of non-malignant IgM monoclonal gammopathy may be phenotypically similar to B-CLL cells.lld:pubmed
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pubmed-article:1701449pubmed:articleTitleThe B-cells that express anti-MAG antibodies in neuropathy and non-malignant IgM monoclonal gammopathy belong to the CD5 subpopulation.lld:pubmed
pubmed-article:1701449pubmed:affiliationDepartment of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY 10032.lld:pubmed
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pubmed-article:1701449pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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