| pubmed-article:1701040 | pubmed:abstractText | Fetal striatal neurons were transplanted into the ibotenic acid lesioned rat striatum. Three months after transplantation the grafted tissue was Golgi-impregnated and examined at the light microscopic level to determine the morphological characteristics of the transplanted neurons. Golgi-impregnated neurons were then gold-toned and examined at the electron microscopic level. The transplanted neurons were classified by both somatic size and somatic and dendritic morphology, which demonstrated that at least seven distinct cell types are present in striatal grafts. Type I large neurons had aspinous somata, sparsely spined dendrites, and indented nuclei, whereas type II large neurons displayed somatic spines, sparsely spined dendrites, and indented nuclei. Type I medium neurons exhibited aspinous somata and proximal dendrites, heavily spined distal dendrites, and unindented nuclei. Type II medium neurons had somatic spines, sparsely spined dendrites, and indented nuclei. Type III medium neurons had aspinous somata, poorly branched and sparsely spined dendrites, and indented nuclei, while type IV medium neurons had aspinous somata, highly branched and sparsely spined dendrites, and indented nuclei. Type V medium neurons displayed aspinous somata, varicose dendrites, and indented nuclei. These results demonstrate that transplanted fetal striatal neurons differentiate into morphologically and ultrastructurally distinct striatal cell types. | lld:pubmed |
