| pubmed-article:17008890 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17008890 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:17008890 | lifeskim:mentions | umls-concept:C0023467 | lld:lifeskim |
| pubmed-article:17008890 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:17008890 | lifeskim:mentions | umls-concept:C1334889 | lld:lifeskim |
| pubmed-article:17008890 | lifeskim:mentions | umls-concept:C1707719 | lld:lifeskim |
| pubmed-article:17008890 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:17008890 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:17008890 | pubmed:dateCreated | 2006-10-25 | lld:pubmed |
| pubmed-article:17008890 | pubmed:abstractText | Activating mutations in NOTCH1 are found in over 50% of human T-cell lymphoblastic leukemias (T-ALLs). Here, we report the analysis for activating NOTCH1 mutations in a large number of acute myeloid leukemia (AML) primary samples and cell lines. We found activating mutations in NOTCH1 in a single M0 primary AML sample, in three (ML1, ML2 and CTV-1) out of 23 AML cell lines and in the diagnostic (myeloid) and relapsed (T-lymphoid) clones in a patient with lineage switch leukemia. Importantly, the ML1 and ML2 AML cell lines are derived from an AML relapse in a patient initially diagnosed with T-ALL. Overall, these results demonstrate that activating mutations in NOTCH1 are mostly restricted to T-ALL and are rare in AMLs. The presence of NOTCH1 mutations in myeloid and T-lymphoid clones in lineage switch leukemias establishes the common clonal origin of the diagnostic and relapse blast populations and suggests a stem cell origin of NOTCH1 mutations during the molecular pathogenesis of these tumors. | lld:pubmed |
| pubmed-article:17008890 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17008890 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17008890 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17008890 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17008890 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17008890 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17008890 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17008890 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17008890 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17008890 | pubmed:issn | 0887-6924 | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:StoneRR | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:AsterJ CJC | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:McKennaKK | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:LookA TAT | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:KalmantiMM | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:CaligiuriM... | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:FoxE AEA | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:SuzukawaKK | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:FerrandoA AAA | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:StiakakiEE | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:PalomeroTT | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:GalinskyII | lld:pubmed |
| pubmed-article:17008890 | pubmed:author | pubmed-author:O-NeilJJ | lld:pubmed |
| pubmed-article:17008890 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17008890 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:17008890 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17008890 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17008890 | pubmed:pagination | 1963-6 | lld:pubmed |
| pubmed-article:17008890 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
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| pubmed-article:17008890 | pubmed:meshHeading | pubmed-meshheading:17008890... | lld:pubmed |
| pubmed-article:17008890 | pubmed:meshHeading | pubmed-meshheading:17008890... | lld:pubmed |
| pubmed-article:17008890 | pubmed:meshHeading | pubmed-meshheading:17008890... | lld:pubmed |
| pubmed-article:17008890 | pubmed:meshHeading | pubmed-meshheading:17008890... | lld:pubmed |
| pubmed-article:17008890 | pubmed:meshHeading | pubmed-meshheading:17008890... | lld:pubmed |
| pubmed-article:17008890 | pubmed:meshHeading | pubmed-meshheading:17008890... | lld:pubmed |
| pubmed-article:17008890 | pubmed:meshHeading | pubmed-meshheading:17008890... | lld:pubmed |
| pubmed-article:17008890 | pubmed:meshHeading | pubmed-meshheading:17008890... | lld:pubmed |
| pubmed-article:17008890 | pubmed:meshHeading | pubmed-meshheading:17008890... | lld:pubmed |
| pubmed-article:17008890 | pubmed:meshHeading | pubmed-meshheading:17008890... | lld:pubmed |
| pubmed-article:17008890 | pubmed:meshHeading | pubmed-meshheading:17008890... | lld:pubmed |
| pubmed-article:17008890 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17008890 | pubmed:articleTitle | Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias. | lld:pubmed |
| pubmed-article:17008890 | pubmed:affiliation | Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA. | lld:pubmed |
| pubmed-article:17008890 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17008890 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17008890 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:4851 | entrezgene:pubmed | pubmed-article:17008890 | lld:entrezgene |
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