| pubmed-article:17005816 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17005816 | lifeskim:mentions | umls-concept:C0026922 | lld:lifeskim |
| pubmed-article:17005816 | lifeskim:mentions | umls-concept:C0332325 | lld:lifeskim |
| pubmed-article:17005816 | lifeskim:mentions | umls-concept:C0915657 | lld:lifeskim |
| pubmed-article:17005816 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:17005816 | pubmed:dateCreated | 2006-9-28 | lld:pubmed |
| pubmed-article:17005816 | pubmed:abstractText | Leprosy responds very slowly to the current multidrug therapy, and hence there is a need for novel drugs with potent bactericidal activity. PA-824 is a 4-nitroimidazo-oxazine that is currently undergoing phase I clinical trials for the treatment of tuberculosis. The activity of PA-824 against Mycobacterium leprae was tested and compared with that of rifampin in axenic cultures, macrophages, and two different animal models. Our results conclusively demonstrate that PA-824 has no effect on the viability of M. leprae in all three models, consistent with the lack of the nitroimidazo-oxazine-specific nitroreductase, encoded by Rv3547 in the M. leprae genome, which is essential for activation of this molecule. | lld:pubmed |
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| pubmed-article:17005816 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17005816 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17005816 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17005816 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17005816 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17005816 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:17005816 | pubmed:author | pubmed-author:KrahenbuhlJam... | lld:pubmed |
| pubmed-article:17005816 | pubmed:author | pubmed-author:BarryClifton... | lld:pubmed |
| pubmed-article:17005816 | pubmed:author | pubmed-author:DowdCynthia... | lld:pubmed |
| pubmed-article:17005816 | pubmed:author | pubmed-author:LahiriRamanuj... | lld:pubmed |
| pubmed-article:17005816 | pubmed:author | pubmed-author:RandhawaBalji... | lld:pubmed |
| pubmed-article:17005816 | pubmed:author | pubmed-author:ManjunathaUjj... | lld:pubmed |
| pubmed-article:17005816 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17005816 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:17005816 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17005816 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17005816 | pubmed:pagination | 3350-4 | lld:pubmed |
| pubmed-article:17005816 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17005816 | pubmed:meshHeading | pubmed-meshheading:17005816... | lld:pubmed |
| pubmed-article:17005816 | pubmed:meshHeading | pubmed-meshheading:17005816... | lld:pubmed |
| pubmed-article:17005816 | pubmed:meshHeading | pubmed-meshheading:17005816... | lld:pubmed |
| pubmed-article:17005816 | pubmed:meshHeading | pubmed-meshheading:17005816... | lld:pubmed |
| pubmed-article:17005816 | pubmed:meshHeading | pubmed-meshheading:17005816... | lld:pubmed |
| pubmed-article:17005816 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17005816 | pubmed:articleTitle | Mycobacterium leprae is naturally resistant to PA-824. | lld:pubmed |
| pubmed-article:17005816 | pubmed:affiliation | Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA. | lld:pubmed |
| pubmed-article:17005816 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17005816 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17005816 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:17005816 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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