| pubmed-article:1700336 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1700336 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1700336 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:1700336 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1700336 | lifeskim:mentions | umls-concept:C0026969 | lld:lifeskim |
| pubmed-article:1700336 | lifeskim:mentions | umls-concept:C0178499 | lld:lifeskim |
| pubmed-article:1700336 | lifeskim:mentions | umls-concept:C1553412 | lld:lifeskim |
| pubmed-article:1700336 | lifeskim:mentions | umls-concept:C1548328 | lld:lifeskim |
| pubmed-article:1700336 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:1700336 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1700336 | pubmed:dateCreated | 1990-12-10 | lld:pubmed |
| pubmed-article:1700336 | pubmed:abstractText | We derived a total of 146 T lymphocyte lines specific for human myelin basic protein (MBP) from the peripheral blood of 20 MS patients and from a control group of 12 healthy donors, and determined the reactivities of T cell lines by [3H]thymidine incorporation on exposure to MBP and MBP peptides 1-44, 45-89, and 90-170. We defined HLA restriction of the T lines by using monoclonal antibodies against monomorphic determinants on human HLA-DR, HLA-DQ, and HLA-DP molecules. MBP-specific T cell lines could be isolated with a comparable efficiency from MS patients and healthy individuals. In both groups, MBP-specific T lymphocytes recognized at least 4 different epitopes in the MBP molecule, and specificities showed comparable patterns for different MBP peptides. MBP-specific T cell lines derived from MS patients and controls were restricted by DR products of the human major histocompatibility class II locus. Notable phenotypic differences of T cell lines existed between the 2 groups. Lines isolated from MS patients expressed predominantly the CD3+ CD4+ CD8- phenotype, while some control lines were composed of up to 87% CD3+CD4+CD8+ T lymphocytes. These findings illustrate the presence of MBP-specific T cells in MS patients and controls that are similarly sensitized to MBP and restricted by HLA-DR products. | lld:pubmed |
| pubmed-article:1700336 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1700336 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1700336 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1700336 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1700336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1700336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1700336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1700336 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1700336 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1700336 | pubmed:issn | 0028-3878 | lld:pubmed |
| pubmed-article:1700336 | pubmed:author | pubmed-author:FujitaKK | lld:pubmed |
| pubmed-article:1700336 | pubmed:author | pubmed-author:AlbertEE | lld:pubmed |
| pubmed-article:1700336 | pubmed:author | pubmed-author:WhitakerJ NJN | lld:pubmed |
| pubmed-article:1700336 | pubmed:author | pubmed-author:WekerleHH | lld:pubmed |
| pubmed-article:1700336 | pubmed:author | pubmed-author:KapposLL | lld:pubmed |
| pubmed-article:1700336 | pubmed:author | pubmed-author:PetteMM | lld:pubmed |
| pubmed-article:1700336 | pubmed:author | pubmed-author:KitzeBB | lld:pubmed |
| pubmed-article:1700336 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1700336 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:1700336 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1700336 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1700336 | pubmed:pagination | 1770-6 | lld:pubmed |
| pubmed-article:1700336 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1700336 | pubmed:meshHeading | pubmed-meshheading:1700336-... | lld:pubmed |
| pubmed-article:1700336 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1700336 | pubmed:articleTitle | Myelin basic protein-specific T lymphocyte lines from MS patients and healthy individuals. | lld:pubmed |
| pubmed-article:1700336 | pubmed:affiliation | Clinical Research Unit for Multiple Sclerosis, Max-Planck-Society, Würzburg, West Germany. | lld:pubmed |
| pubmed-article:1700336 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1700336 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1700336 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:1700336 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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