| pubmed-article:17002669 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17002669 | lifeskim:mentions | umls-concept:C1089114 | lld:lifeskim |
| pubmed-article:17002669 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17002669 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:17002669 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:17002669 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17002669 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:17002669 | pubmed:dateCreated | 2006-9-27 | lld:pubmed |
| pubmed-article:17002669 | pubmed:abstractText | The present study was performed to investigate the hepatoprotective and hypolipidaemic effects of a 27 kDa glycoprotein isolated from Gardenia jasminoides Ellis (GJE glycoprotein) in glucose/glucose oxidase (G/GO)-treated BNL CL.2 cells, as well as in CCl4, Triton WR-1339 and corn oil-treated mice. In G/GO-treated BNL CL.2 cells, the results showed that GJE glycoprotein has an inhibitory effect on G/GO-induced cytotoxicity and intracellular reactive oxygen species production. In addition, GJE glycoprotein has an anti-oxidant effect against the lipid peroxidation process in the Fe2+/ascorbic acid system. In CCl4 (1.0 mL/kg)-treated mice, pretreatment with GJE glycoprotein (80 mg/kg) blocked lactate dehydrogenase release and the formation of thiobarbituric acid-reactive substances. In addition, in these mice GJE resulted in increased nitric oxide production and the activation of anti-oxidant enzymes, accompanied by the inhibition of the cytotoxic-related signals hepatic cytochrome c, nuclear factor-kappaB and activator protein-1. In both Triton WR-1339 (400 mg/kg) and corn oil (1.0 g/kg)-treated mice, pretreatment with GJE glycoprotein (80 mg/kg) lowered the levels of plasma lipoproteins (triglyceride, total cholesterol and low-density lipoprotein). On the basis of these results, we assume that GJE glycoprotein can ameliorate liver function, because it has hepatoprotective and hypolipidaemic activities. | lld:pubmed |
| pubmed-article:17002669 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17002669 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17002669 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17002669 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17002669 | pubmed:issn | 0305-1870 | lld:pubmed |
| pubmed-article:17002669 | pubmed:author | pubmed-author:LimKye-TaekKT | lld:pubmed |
| pubmed-article:17002669 | pubmed:author | pubmed-author:LeeSei-JungSJ | lld:pubmed |
| pubmed-article:17002669 | pubmed:author | pubmed-author:OhPhil-SunPS | lld:pubmed |
| pubmed-article:17002669 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17002669 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:17002669 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17002669 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17002669 | pubmed:pagination | 925-33 | lld:pubmed |
| pubmed-article:17002669 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:17002669 | pubmed:meshHeading | pubmed-meshheading:17002669... | lld:pubmed |
| pubmed-article:17002669 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17002669 | pubmed:articleTitle | Hepatoprotective and hypolipidaemic effects of glycoprotein isolated from Gardenia jasminoides ellis in mice. | lld:pubmed |
| pubmed-article:17002669 | pubmed:affiliation | Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University, Kwangju, South Korea. | lld:pubmed |
| pubmed-article:17002669 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17002669 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17002669 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17002669 | lld:pubmed |
